Séverine BOILLÉE

Biography

Séverine Boillée heads the team “Causes of ALS and Mechanisms of Motor Neuron Degeneration” at Paris Brain Institute and is Research Officer at INSERM. She obtained her Neurosciences thesis in 2001 at the University of Paris XII and specialized in ALS during her post-doc at UCSD with Prof. Don W Cleveland. In 2011, together with Professor Vincent Meininger, she received the “NRJ-Institut de France” award for her research on ALS. She is a member of the Scientific Council of the Thierry Latran Foundation (European association of ALS), the ARSLA (French association of ALS) and the Executive Committee of the Medical Branch of Rare Diseases of ALS (FILSLAN).

Research

Interests: amyotrophic lateral sclerosis (ALS), motoneuron, neurodegeneration, neuroinflammation, microglia/macrophage Séverine BOILLEE's team is studying the mechanisms of motoneuron degeneration (MN) in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease or Charcot's disease) resulting from pathological interactions between MN and microglia/macrophages in order to find promising therapeutic pathways to slow the progression of the disease. Séverine BOILLEE's projects focus on:

• To understand how peripheral macrophages influence NM survival and disease progression in ALS.
• To determine how the macrophages of ALS patients differ from control macrophages in order to find new pathways involved in disease progression.

Main publications

• Ribon M, Leone C, Chiot A, Berriat F, Rampanana M, Cottin J, Bohl D, Millecamps S, Lobsiger CS, Heneka MT, Boillée S. Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. Neurobiol Aging. 2021 May;101:181-186. PMID: 33626479
• Chiot A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS, Boillée S. Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival. Nat Neurosci. 2020 Nov;23(11):1339-1351. PMID: 33077946
• Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S.  System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain. 2015 Jan;138(Pt 1):53-68. PMID: 25384799
• Lobsiger CS*, Boillée S*, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW.  C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92. PMID: 24170856 (* equal contribution)
• Boillée S*, Yamanaka K*, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW.Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006 Jun 2;312(5778):1389-92. PMID: 16741123 (* equal contribution)