The objective of the iCRIN is to develop interactions and sharing of expertise between the stakeholders of the Department of Medical-University (DMU) of Neurosciences of the Pitié-Salpêtrière Hospital and the research teams of the Brain Institute. The projects were evaluated by the Scientific Advisory Board of Paris Brain Institute on the expertise, performance, quality and visibility of the structure. 13 projects have been selected and officially started in 2019, backed by the Clinical Investigation Centre of Paris Brain Institute.
By placing the patient at the heart of its concerns, Paris Brain Institute pursues one objective: to develop innovative therapeutic solutions that revolutionize the treatment of neurological and psychiatric diseases.
Bringing basic and clinical research together to maximize the chance of a discovery being translated into treatment is therefore paramount and integral to the Institute’s model. It is from this clear perspective that the unique iCRIN model was created. The objective of these structures is to develop shared expertise between the caregivers of Pitié-Salpêtrière Hospital and the research teams of Paris Brain Institute.
Stroke, Alzheimer’s and Parkinson’s diseases, neurogenetics, neuro-oncology… Organized around 13 key themes exploring all fields of the fight against brain diseases, iCRIN is an accelerator of success for the many clinical research projects of the care services of the ecosystem of Paris Brain Institute.
Alzheimer's Disease
In collaboration with the Institute for Memory and Alzheimer’s Disease (IM2A), this project aims to: identify new cognitive markers and group specific populations of patients with Alzheimer’s disease; develop clinical applications, increasing preclinical and clinical trials, and proof of concept studies. To this end, iCRIN is building and monitoring cohorts of patients suffering from neurodegenerative diseases, whose clinical, biological and neuroimaging data will be organized into databases.
Parkinson's disease and movement disorders
The iCRIN dedicated to Parkinson’s disease and movement disorders benefits from the synergies between the team of Olga Corti and Jean-Christophe Corvol and that of Marie Vidailhet and Stéphane Lehéricy. Its two main objectives are to identify biomarkers of disease severity, disease progression and treatment response, and to decipher pathophysiologic mechanisms underlying behavioural and motor control disorders in rare movement disorders.
Amyotrophic Lateral Sclerosis (ALS)
The SLA centre in Paris is one of the most important in Europe, both in terms of new patients and patients monitored. He collaborates with several members of the team of Séverine Boillée at Paris Brain Institute. The iCRIN SLA is composed of four axes: to elucidate the triggering of Amyotrophic Lateral Sclerosis (ALS or Charcot’s disease) and to identify biomarkers; to understand the phenomenon of propagation of motoneuron dysfunction; to discover why mechanisms of innervation compensation are maintained in certain patients; to study the effect of the opening of the blood-brain barrier by focusing ultrasound in ALS.
Neurological Intensive Care
The Neurological Intensive Care Unit is a highly experienced facility for the acute management of patients with peripheral and/or central nervous system disorders. His activity focuses on four main pathologies: the categorization and monitoring of disorders of consciousness in collaboration with the team of Lionel Naccache; the diagnosis and therapeutics of states of epilepsy with the team of Stéphane Charpier and Vincent Navarro; the early diagnosis of encephalitis; the creation of a large clinical database in myasthenia.
Neurosurgery
Virtually all of the clinical activities of the neurosurgery department have research programs with Paris Brain Institute teams and platforms. The iCRIN aims to ensure the development of multi-modal databases of future clinical trials. Five main lines of research: identification of factors predictive of morbidity and mortality in cohorts of patients with brain tumours and aneurysms; new targets for deep brain stimulation and brain-brain interfaces; opening of the blood-brain barrier in various neurological pathologies; new therapeutic approaches for meningitis; ex vivo human tissue for cellular electrophysiology.
Neurogenetics
The clinical research centre NEUROLOP, including the actors of the Rare Diseases Reference Centres of the Department of Genetics of the Hospital and Paris Brain Institute, aims to decipher the phenotypes associated with genes involved in neurogenetic pathologies such as spinocerebral ataxia or Huntington’s disease, from birth to adulthood; the search for clinical, imaging, biological and genetic biomarkers; innovative therapeutic trials in The transition from neurodevelopmental defects to programmed neuron loss in adulthood in neurogenetic diseases related to basic research.
Neuro-oncology
The association of the Department of Neuro-Oncology with a dedicated research team, led by Marc Sanson and Emmanuelle Huillard at Paris Brain Institute, a unique tumour bank (Onconeurotek), a pre-clinical therapeutic research group (GlioTex, led by Ahmed Idbaih) and a certification from the National Cancer Institute for early phase clinical trials and advanced therapies make it possible to achieve the following objectives: In this context, the Commission will continue to support the development of the European Research Area (ERA) and the European Research Area (ERA).
Stroke
The objectives of the stroke iCRIN are: participation/coordination of randomised controlled trials, use of Big Data to construct a dynamic prognostic model of the outcome of a cerebral vascular accident (stroke); identification of new structural and functional markers of the consequences of stroke; development of innovative therapeutic approaches in rehabilitation, such as non-invasive brain stimulation techniques, playful and innovative rehabilitation strategies. (serious games, neurofeedback) or pharmacological treatments.
Orthopaedic surgery
The clinical project of the Pitié-Salpêtrière department of orthopaedics focuses on three main themes: the genetic etiology of idiopathic scoliosis, in collaboration with Claire Wyart’s team at Paris Brain Institute; the establishment of a systematic registry of neurological status before and after the operation for all patients in the spinal unit; the development of various prospective analysis protocols linking neurosciences with sports surgeries or surgeries; and the development of a system for the diagnosis of idiopathic scoliosis. spinal cord injuries.
Adult Psychiatry
The iCRIN Psychiatry offers a multi-modal approach combining brain stimulation with pharmacotherapy or psychotherapy. It represents a strong interface between clinical services and Paris Brain Institute, particularly with the team of Philippe Fossati and Liane Schmidt. Two lines of research are currently being explored: the development of pragmatic trials in stress dysregulation disorders, such as post-traumatic stress disorder; the exploration of neuromodulation of psychiatric networks; and drug use disorders.
Head injuries
New approaches to integrating multi-modal data are critical for tracking brain vulnerability, individual trajectories, and the progression of head injuries (CBT). This iCRIN aims to structure and develop a large prospective cohort of head trauma patients explored in a multimodal way (clinical, radiology, physiology), and to develop the modelling of the results, including using statistical learning techniques.
Multiple sclerosis
In the rapidly evolving field of sleep physiology and medicine, this iCRIN focuses on better describing the semiology of these disorders, their genetics, and neurophysiological and brain imaging markers and their optimal treatment. It also aims to understand the mechanisms of normal sleep and dreaming; to determine whether certain brain functions (for example, memory or emotions) are related to REM sleep or not; to study preclinical neurodegeneration and to try neuroprotective treatments in patients with Parkinson’s disease and Lewy body dementia.
