Neurological diseases are defined as dysfunction of the central or peripheral nervous system. They may be genetic, mental, traumatic or idiopathic.
An estimated 6.8 million people die each year from neurological disorders, and the proportion of people with these disorders is proportional to the percentage of the population over the age of 65.
However, this percentage is rising steadily and it is estimated that in France the 65 and over group will account for 17.8% of the population in 2060.
This ageing of the population and the increasing prevalence of neurological diseases have led to a massive investment by states in understanding and combating diseases of the nervous system with medical objectives that include prevention, therapeutic management and medical personalisation.
Population projections of the incidence of neurological diseases (Report 2015)
Addressing the challenges
Faced with its challenges, Paris Brain Institute, thanks to a unique ecosystem combining basic and clinical research, technological plateaux at the cutting edge of innovation and a close partnership with entrepreneurship, has the capacity to understand optimally the understanding of the nervous system and the therapeutic management of its pathologies.
Research at Paris Brain Institute focuses only on chronic, inflammatory and traumatic neurological diseases of the central nervous system, that is, diseases that originate in the brain and spinal cord.
Nevertheless, some of its pathologies have consequences on the peripheral nervous system, in particular on motor skills, sensitivity and sometimes even in the longer term on so-called autonomous functions such as breathing.
Understanding the difference between the central and peripheral nervous systems
Neuroscientists, psychiatrists and neurologists work together to conduct world-class, state-of-the-art research to understand the healthy brain and the brain affected by disease and to accelerate the availability of new medical treatments and devices.
Rare neurological diseases
A disease is said to be rare when it affects less than one person in 2,000. More than 7,000 rare diseases - including around 800 neurological ones - are described, and new ones are identified every week.
These pathologies are characterized by a wide variety of clinical signs, which differ not only from one disease to another, but also between two patients suffering from the same disease. This variability makes diagnosis difficult, with the latter occurring on average 5 years after the onset of symptoms in 25% of cases; particularly in the case of non-hereditary diseases, which account for 20% of cases.
Neurological diseases studied at Paris Brain Institute
- Alzheimer’s Disease
- Epilepsy
- Parkinson's disease
- Plaque Sclerosis (SEP)
- Charcot’s Disease — ALS
- Huntington’s Disease
- Dystonia
- Progressive Supranuclear Palsy (PSP)
- Prion Diseases
- Ataxia
- spastic paraplegia
- Brain Tumours
- The Cerebral Vascular Accident (Stroke)
- Spinal cord injuries
- Head injuries
- Fronto-temporal degeneration (FTD)