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Why does the same genetic mutation cause a severe brain malformation in some patients but not in others? Researchers from the MOSAIC team at the Paris Brain Institute have developed mosaic human cortical organoids carrying mutations in the DEPDC5...

Researchers from the Paris Brain Institute and Sainte-Justine University Hospital in Montreal have, for the first time, revealed the key stages of vascular development in the brain, from birth through adulthood. Using a 3D digital atlas called...

Attention-deficit/hyperactivity disorder (ADHD) remains poorly understood from a biological perspective. An international study led by scientists from the Paris Brain Institute and Monash University in Australia suggests that some symptoms may be...

Can brain imaging reveal whether a person is affected by depression? This question has driven research for many years. Changes in brain structure have indeed been observed in patients with depression, suggesting that structural MRI might one day help...

Many patients suffer from epilepsy that cannot be controlled by current medications. Surgical removal of epileptogenic brain regions is effective in only about half of cases, and not all patients are eligible for the procedure. For these individuals...

An international team led by Jaime de Juan-Sanz at the Paris Brain Institute has shown that slightly increasing the metabolic capacity of neurons can enhance long-term memory in both fruit flies and mice. The study, published in Nature Metabolism...