DecodeALS

The team’s goal is to identify pathways as therapeutic targets for slowing disease progression through 2 approaches:

• To understand how mutations in known or identifiable genes cause motoneuron death and microglial dysfunction.
• Discovering new therapeutic targets related to the immune system and the periphery (rather than the central nervous system (easier to access than the brain) by modulating the response of peripheral macrophages to spinal cord motoneuron degeneration.

Main publications

• Montero AS*, Aliouat I*, Ribon M, Canney M, Goldwirt L, Mourah S, Berriat F, Lobsiger CS, Pradat PF, Salachas F, Bruneteau G, Carpentier A, Boillée S.
  Effect of ultrasound-mediated blood-spinal cord barrier opening on survival and motor function in females in an amyotrophic lateral sclerosis mouse model.
  EBioMedicine. 2024 Aug;106:105235. PMID: 38996764 
• Berriat F*, Lobsiger CS*, Boillée S.
  The contribution of the peripheral immune system to neurodegeneration.
  Nat Neurosci. 2023 Jun;26(6):942-954. PMID: 37231108
  (Review)
• Lefebvre-Omar C, Liu E, Dalle C, d'Incamps BL, Bigou S, Daube C, Karpf L, Davenne M, Robil N, Jost Mousseau C, Blanchard S, Tournaire G, Nicaise C, Salachas F, Lacomblez L, Seilhean D, Lobsiger CS, Millecamps S, Boillée S, Bohl D.
  Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity.
  Cell Mol Life Sci. 2023 May 15;80(6):150. PMID: 37184603
• Teyssou E, Chartier L, Roussel D, Perera ND, Nemazanyy I, Langui D, Albert M, Larmonier T, Saker S, Salachas F, Pradat PF, Meininger V, Ravassard P, Côté F, Lobsiger CS, Boillée S, Turner BJ, Seilhean D, Millecamps S.
  The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
  Int J Mol Sci. 2022 May 19;23(10):5694. PMID: 35628504
• Muratet F, Teyssou E, Chiot A, Boillée S, Lobsiger CS, Bohl D, Gyorgy B, Guegan J, Marie Y, Amador MDM, Salachas F, Meininger V, Bernard E, Antoine JC, Camdessanché JP, Camu W, Cazeneuve C, Fauret-Amsellem AL, Leguern E, Mouzat K, Guissart C, Lumbroso S, Corcia P, Vourc'h P, Grapperon AM, Attarian S, Verschueren A, Seilhean D, Millecamps S.
  Impact of a frequent nearsplice SOD1 variant in amyotrophic lateral sclerosis: optimising SOD1 genetic screening for gene therapy opportunities.
  J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):942-949. PMID: 33785574
• Ribon M, Leone C, Chiot A, Berriat F, Rampanana M, Cottin J, Bohl D, Millecamps S, Lobsiger CS, Heneka MT, Boillée S.
  Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice.
  Neurobiol Aging. 2021 May;101:181-186. PMID: 33626479
• Teyssou E, Muratet F, Amador MD, Ferrien M, Lautrette G, Machat S, Boillée S, Larmonier T, Saker S, Leguern E, Cazeneuve C, Marie Y, Guegan J, Gyorgy B, Cintas P, Meininger V, Le Forestier N, Salachas F, Couratier P, Camu W, Seilhean D, Millecamps S.
  Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
  Neurobiol Aging. 2021 Mar;99:102.e11-102.e20. PMID: 33218681
• Amador MD, Muratet F, Teyssou E, Boillée S, Millecamps S.
  New advances in Amyotrophic Lateral Sclerosis genetics: Towards gene therapy opportunities for familial and young cases.
  Rev Neurol (Paris). 2021 May;177(5):524-535. PMID: 33810837
  (Review.)
• Chiot A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS, Boillée S.
  Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
  Nat Neurosci. 2020 Nov;23(11):1339-1351. PMID: 33077946 
• Amador MD, Muratet F, Teyssou E, Banneau G, Danel-Brunaud V, Allart E, Antoine JC, Camdessanché JP, Anheim M, Rudolf G, Tranchant C, Fleury MC, Bernard E, Stevanin G, Millecamps S.
  Spastic paraplegia due to recessive or dominant mutations in ERLIN2 can convert to ALS.
  Neurol Genet. 2019 Nov 13;5(6):e374. PMID: 32042907 
• Chiot A, Lobsiger CS, Boillée S.
  New insights on the disease contribution of neuroinflammation in amyotrophic lateral sclerosis.
  Curr Opin Neurol. 2019 Oct;32(5):764-770. PMID: 31306211 
  (Review)
• Teyssou E*, Chartier L*, Amador MD, Lam R, Lautrette G, Nicol M, Machat S, Da Barroca S, Moigneu C, Mairey M, Larmonier T, Saker S, Dussert C, Forlani S, Fontaine B, Seilhean D, Bohl D, Boillée S, Meininger V, Couratier P, Salachas F, Stevanin G, Millecamps S.
  Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis.
  Neurobiol Aging. 2017 Oct;58:239.e11-239.e20. PMID: 28716533
• Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S.
  System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice.
  Brain. 2015 Jan;138(Pt 1):53-68. PMID: 25384799