Speaker : Thijs VAN OSCH, University Leiden professor experimental cerebrovascular imaging.
"Human brain clearance MRI"
Brain clearance via perivascular spaces was proposed a decade ago under the term ‘Glymphatics’. Most of these studies were performed in rodents with only recently more human studies being performed. Many questions like the exact pathway and the driving forces of glymphatics are still open. For human brain clearance imaging there is not yet a golden standard, although intrathecal contrast agent enhanced MRI is considered to be the best approach at the moment. However, the temporal footprint of this technique is long (24-48 hours). It is therefore essential to develop non-invasive human brain clearance MRI that allows high enough temporal resolution to study the driving forces involved. In this presentation, several approaches will be presented: arterial spin labelling measurements to probe the transport times of water from blood to tissue and from blood to CSF, high resolution 7 TeslaMRI with a long echo time in combination with motion sensitising gradients to measure CSF mobility in perivascular spaces, and combined BOLD and CSF-flow measurements in the fourth ventricle.
Hosted by Francesca BRANZOLI.
If you would like to meet the speaker, please contact us.
Conference location
Please join the conference in Paris Brain Institute auditorium.