Benoît DELATOUR

In the multidisciplinary study of mouse models of Alzheimer's disease, their objective is twofold: first, they are studying the morphofunctional consequences of deposition of Aß. They found that plaque-bearing mice experience significant brain atrophy, white matter damage, neuronal loss, decreased neurogenic activity, and age-related neurological and cognitive impairments. Second, they used mouse models as precision tools to implement new imaging strategies to detect Alzheimer brain damage in vivo. Finally, the rationale for their work on animal models is:

1. to dissect histopathological markers of AD and their clinical relevance to trigger further therapeutic trials.
2. to develop new neuroimaging methods for early detection of the disease.

Focus: Alzheimer's disease, neuropathology, animal models, animal behaviour, histology