Olga CORTI
Title: PhD
Function: Team Leader, PI
Affiliated entities INSERM
Biography
Olga Corti obtained a bachelor's degree in biology from the University of Milan (1992). She then studied molecular biology at the Carlo Besta Neurological Institute (laboratory of S. Di-Donato, 1990-1993). She obtained a doctorate in neurobiology at the Pierre and Marie Curie University in Paris, after conducting research in the field of experimental gene therapy for Parkinson's disease (laboratory of J. Mallet, CNRS, 1994-1999; thesis prize of the French Society of Neurosciences). After a post-doctorate devoted to the functional exploration of one of the first genes described as responsible for familial forms of Parkinson's disease (laboratory of A. Brice, Inserm, 2000-2003), she was recruited as a senior researcher at Inserm. She currently co-leads the Molecular Physiopathology of Parkinson's Disease team at Paris Brain Institute.
Research
Dr. Olga Corti is interested in the pathological mechanisms of Parkinson's disease, with a focus on familial forms of Parkinson's disease, including PRKN-related Parkinson's disease. Her research combines complementary approaches of biochemistry and molecular and cellular biology with mouse models and patient-derived cells, including neurons derived from induced pluripotent stem cells, to study the impact of Parkinson's disease mutations on quality control and mitochondrial function, cellular vulnerability to stress and innate immunity.
Main publications
- Jacoupy M, Hamon-Keromen E, Ordureau A, Erpapazoglou Z, Coge F, Corvol JC, Nosjean O, Mannoury la Cour C, Millan MJ, Boutin JA, Harper JW, Brice A, Guedin D, Gautier CA, Corti O. L'ubiquitine ligase Parkin, pilotée par la kinase PINK1, favorise l'importation des protéines mitochondriales par la voie de la préséquence dans les cellules vivantes. Sci Rep. 2019 Aug 14;9(1):11829. doi : 10.1038/s41598-019-47352-9.
- Bonello F, Hassoun SM, Mouton-Liger F, Shin YS, Muscat A, Tesson C, Lesage S, Beart PM, Brice A, Krupp J, Corvol JC, Corti O. LRRK2 impairs PINK1/Parkin-dependent mitophagy via son activité kinase : pathologic insights into Parkinson's disease. Hum Mol Genet. 2019 15 mai;28(10):1645-1660. doi : 10.1093/hmg/ddz004.
- Mouton-Liger F, Rosazza T, Sepulveda-Diaz J, Ieang A, Hassoun SM, Claire E, Mangone G, Brice A, Michel PP, Corvol JC, Corti O. La déficience en parkine module l'activation de l'inflammasome NLRP3 en atténuant une boucle de rétroaction négative dépendante de l'A20. Glia. 2018 ; 66(8):1736-1751. doi : 10.1002/glia.23337.
- Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S, Duffaure S, Girard M, Foret B, Iannielli A, Broccoli V, Dalle C, Bohl D, Michel PP, Corvol JC, Brice A, Corti O. L'interface réticulum endoplasmique-mitochondrie est perturbée chez les souris knockout PARK2 et les patients présentant des mutations PARK2. Hum Mol Genet. 2016;25(14):2972-2984. doi : 10.1093/hmg/ddw148.
- Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T,Maurage CA, Sahbatou M, Liebau S,Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet V, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DJ, Heutink P, J. Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF,Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O*, Brice A* . La perte de la fonction VPS13C dans le parkinsonisme autosomique récessif provoque un dysfonctionnement mitochondrial et augmente la mitophagie dépendante de PINK1/Parkin. Am J Hum Genet 2016;98(3):500-13.