Experimental Neurosurgery

The lines of research of the "Experimental Neurosurgery" team are:

• Understanding the anatomy of networks involving targets of deep neurostimulation
• Identify mechanisms of these targets using electrophysiology coupled with behavioural testing
• Develop a new approach to test whether neurofeedback, training patients to control their brain activity, can be used to regulate the effect of deep stimulation.

Main publications

• Lau B., Meier N., Serra G., Czernecki V., Schuepbach M., Navarro S., Cornu P., Grabli D., Agid Y., Vidailhet M., Karachi C., Welter M.-L. (2019): Axial symptoms predict mortality in patients with Parkinson disease and subthalamic stimulation. Neurology. 92: 2559-2570.
• Karachi C., Cormier-Dequaire F., Grabli D., Lau B., Belaid H., Navarro S., Vidailhet M., Bardinet E., Fernandez-Vidal S., Welter M.-L. (2019): Clinical and anatomical predictors for freezing of gait and falls after subthalamic deep brain stimulation in Parkinson’s disease patients. Parkinsonism & Related Disorders. 62: 91-97.
• Sébille S.*, Rolland A.-S.*, Faillot M., Perez-Garcia F., Colomb-Clerc A., Lau B., Dumas S., Fernandez Vidal S., Welter M.-L., Francois C., Bardinet E., Karachi C. (2019): Normal and pathological neuronal distribution of the human mesencephalic locomotor region. Movement Disorders. 34: 218-227.
• Welter M.-L., Houeto J.L., Thobois S., Bataille B., Guenot M., Worbe Y., Hartmann A., Czernecki V., Bardinet E., Yelnik J., Tezenas du Montcel S., Agid Y., Vidailhet M., Cornu P., Tanguy A., Ansquer S., Jaafari N., Poulet E., Serra G., Burbaud P., Cuny E., Aouizerate B., Pollak P., Chabardes S., Polosan M., Borg M., Fontaine D., Giordana B., Raoul S., Rouaud T., Sauvaget A., Jalenques I., Karachi C., Mallet L., for the STIC study group. (2017): Anterior pallidal deep brain stimulation for Tourette’s syndrome: a
  double-blind randomized parallel controlled trial. Lancet Neurology. 16:610-619.
• Sébille S.*, Belaid H.*, Philippe A., André A., Lau B., François F., Karachi C., Bardinet E. (2016): Anatomical evidence for functional diversity in the mesencephalic locomotor region of primates. NeuroImage. 147: 66-78.
• Lau B., Welter M.-L., Belaid H., Fernandez Vidal S., Bardinet E., Grabli D., Karachi C. (2015): The integrative role of the pedunculopontine nucleus in human gait. Brain. 138: 1284–1296.