Brian LAU
Dr (PhD), Team Leader, PI, CNRS
Carine KARACHI
Dr (MD, PhD), Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Team presentation
The objective of the team is to characterize the anatomy of the cortical region and the physiology of brain networks involved in motor control. The ultimate goal of this work is to develop new therapies and applications for deep brain stimulation.
The lines of research of the "Experimental Neurosurgery" team are:
- Understanding the anatomy of networks involving targets of deep neurostimulation
- Identify mechanisms of these targets using electrophysiology coupled with behavioural testing
- Develop a new approach to test whether neurofeedback, training patients to control their brain activity, can be used to regulate the effect of deep stimulation.
Main publications
- Lau B., Meier N., Serra G., Czernecki V., Schuepbach M., Navarro S., Cornu P., Grabli D., Agid Y., Vidailhet M., Karachi C., Welter M.-L. (2019): Axial symptoms predict mortality in patients with Parkinson disease and subthalamic stimulation. Neurology. 92: 2559-2570.
- Karachi C., Cormier-Dequaire F., Grabli D., Lau B., Belaid H., Navarro S., Vidailhet M., Bardinet E., Fernandez-Vidal S., Welter M.-L. (2019): Clinical and anatomical predictors for freezing of gait and falls after subthalamic deep brain stimulation in Parkinson’s disease patients. Parkinsonism & Related Disorders. 62: 91-97.
- Sébille S.*, Rolland A.-S.*, Faillot M., Perez-Garcia F., Colomb-Clerc A., Lau B., Dumas S., Fernandez Vidal S., Welter M.-L., Francois C., Bardinet E., Karachi C. (2019): Normal and pathological neuronal distribution of the human mesencephalic locomotor region. Movement Disorders. 34: 218-227.
- Welter M.-L., Houeto J.L., Thobois S., Bataille B., Guenot M., Worbe Y., Hartmann A., Czernecki V., Bardinet E., Yelnik J., Tezenas du Montcel S., Agid Y., Vidailhet M., Cornu P., Tanguy A., Ansquer S., Jaafari N., Poulet E., Serra G., Burbaud P., Cuny E., Aouizerate B., Pollak P., Chabardes S., Polosan M., Borg M., Fontaine D., Giordana B., Raoul S., Rouaud T., Sauvaget A., Jalenques I., Karachi C., Mallet L., for the STIC study group. (2017): Anterior pallidal deep brain stimulation for Tourette’s syndrome: a
double-blind randomized parallel controlled trial. Lancet Neurology. 16:610-619. - Sébille S.*, Belaid H.*, Philippe A., André A., Lau B., François F., Karachi C., Bardinet E. (2016): Anatomical evidence for functional diversity in the mesencephalic locomotor region of primates. NeuroImage. 147: 66-78.
- Lau B., Welter M.-L., Belaid H., Fernandez Vidal S., Bardinet E., Grabli D., Karachi C. (2015): The integrative role of the pedunculopontine nucleus in human gait. Brain. 138: 1284–1296.
Team members
Brian LAU
Dr (PhD), Team Leader, PI, CNRS
Carine KARACHI
Dr (MD, PhD), Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Nathalie GEORGE
Scientific Director of CENIR MEG-EEG, DR1, PI, CNRS
Marie-Laure WELTER
Project Sponsor, MD, PhD, PU-PH, PI
Jérôme MUNUERA
Postdoctorant, PhD, PI