Emmanuel MANDONNET

After studying physics at the Ecole normale supérieure in Lyon and obtaining a doctorate in quantum physics, Emmanuel Mandonnet began his medical studies in 2000 at the Faculty of Paris 5. From 2003 to 2008, he was in charge of neurosurgery in Paris hospitals. In parallel, he developed a research activity focusing on the biomathematical modelling of gliomas. Hospital practitioner - Professor of universities since 2015 in the neurosurgery department of the Lariboisière hospital, he invests in surgery of intracerebral tumours (gliomas, metastases). In particular, he specializes in "waking" surgery to optimize the preservation of cognitive functions. Having obtained an INSERM interface contract in 2018 within the Frontlab at Paris Brain Institute, he is now focusing his research on the electrophysiological and functional aspects of intracerebral surgery: recording and interpretation of intraoperative evoked potentials, pre- and post-operative evaluations of high-level cognitive functions, tools for predicting postoperative and socio-professional cognitive development based on pre-operative cognitive data. and imaging (resting fMRI, tractography). Major search indices: factor-h = 40, indexed papers pubmed = 140.

• predicting the effect of surgical resection on cognitive functions using machine learning methods
• deciphering brain connections by the method of intra-operative evoked potentials
• exploration of high-level cognitive functions (creativity, decision-making related to fatigability, ...) in patients being followed for a brain tumour
• multimodal methods (functional and structural connectivity MRI, evoked potentials and intraoperative cognitive mapping) of brain network exploration