Emmanuelle HUILLARD
PhD, Team Leader, PI
Matthieu PEYRE
Clinician, MD,PhD,MCU-PH, Team Leader, PI, Sorbonne Université, AP-HP
Team presentation
Understanding the structure and function of neurovascular interfaces in health and disease, in the context of vascular malformations and brain tumors.
The four main objectives are:
- Improving diagnosis and treatment by developing a molecular database
- Characterize the function of new mutations identified in gliomas using an analytical "pipeline" developed by the team
- Identify the intrinsic and microenvironment-related cellular mechanisms responsible for tumour development and progression
- Develop new mouse and human models for validating new treatments
Main publications
- Touat M et al. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 Apr;580(7804):517-523.
- Di Stefano AL et al. Clinical, Molecular and Radiomic Profile of Gliomas With FGFR3-TACC3 Fusions. Neuro Oncol 2020 May 15:noaa121. doi: 10.1093/neuonc/noaa121.
- D’Angelo F et al. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med. 2019 Jan;25(1):176-187.
- Idbaih A et al. Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma. Clin Cancer Res. 2019 Jul 1;25(13):3793-3801.
- Rosenberg S et al. A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas. Nat Commun. 2018 Jun 18;9(1):2371
- Labreche K et al. Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci. Acta Neuropathol. 2018 May;135(5):743-755.
- Peyre M, et al. Progestin-associated shift of meningioma mutational landscape. Ann Oncol 2018 Mar 1;29(3):681-686.
- Frattini V et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018 Jan 11;553(7687):222-227
Team members
Emmanuelle HUILLARD
PhD, Team Leader, PI
Matthieu PEYRE
Clinician, MD,PhD,MCU-PH, Team Leader, PI, Sorbonne Université, AP-HP
Jean-Leon THOMAS
Project Sponsor, PhD, DR1, PI, INSERM
Stéphanie LENCK
Interventional Neuroradiologist, PhD student, PI
Michel KALAMARIDES
Project Sponsor, MD, PhD, PU-PH, PI, Sorbonne Université, AP-HP
