Spinal Sensory Signage

The main objectives are:

• The study of innate physiological functions (neuromodulation and peptide secretion) and their effect on the activity of RSN neurons and neurons in contact with cerebrospinal fluid.
• The study of the mechanisms linking cerebrospinal fluid and the formation of the dorsal axis and scolioses
• The development of new strategies for the management of spinal cord injuries (mechanical and inflammatory) is leading to molecular and cellular studies in collaboration with Professor Mousselard.

• Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. Thouvenin O, Keiser L, Cantaut-Belarif Y, Carbo-Tano M, Verweij F, Jurisch-Yaksi N, Bardet PL, van Niel G, Gallaire F, Wyart C. Elife. 2020 Jan 9;9:e47699. doi: 10.7554/eLife.47699.
• Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo. Orts-Del'Immagine A, Cantaut-Belarif Y, Thouvenin O, Roussel J, Baskaran A, Langui D, Koëth F, Bivas P, Lejeune FX, Bardet PL, Wyart C. Curr Biol. 2020 Mar 9;30(5):827-839.e4. doi: 10.1016/j.cub.2019.12.071. Epub 2020 Feb 20.
• A calibrated optogenetic toolbox of stable zebrafish opsin lines. Antinucci P, Dumitrescu A, Deleuze C, Morley HJ, Leung K, Hagley T, Kubo F, Baier H, Bianco IH, Wyart C. Elife. 2020 Mar 27;9:e54937. doi: 10.7554/eLife.54937.
• Somatostatin 1.1 contributes to the innate exploration of zebrafish larva. Quan FB, Desban L, Mirat O, Kermarquer M, Roussel J, Koëth F, Marnas H, Djenoune L, Lejeune FX, Tostivint H, Wyart C. Sci Rep. 2020 Sep 17;10(1):15235. doi: 10.1038/s41598-020-72039-x.
• Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK. Neuron. 2020 Nov 25;108(4):623-639.e10. doi: 10.1016/j.neuron.2020.08.024. Epub 2020 Sep 21.
• Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture. Oldfield CS, Grossrubatscher I, Chávez M, Hoagland A, Huth AR, Carroll EC, Prendergast A, Qu T, Gallant JL, Wyart C, Isacoff EY. Elife. 2020 Sep 28;9:e56619. doi: 10.7554/eLife.56619.
• Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development. Cantaut-Belarif Y, Orts Del'Immagine A, Penru M, Pézeron G, Wyart C, Bardet PL. Elife. 2020 Oct 13;9:e59469. doi: 10.7554/eLife.59469.
• Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos. Thouvenin O, Cantaut-Belarif Y, Keiser L, Gallaire F, Wyart C. Bio Protoc. 2021 Mar 5;11(5):e3932. doi: 10.21769/BioProtoc.3932. eCollection 2021 Mar 5.
• Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed. Wu MY, Carbo-Tano M, Mirat O, Lejeune FX, Roussel J, Quan FB, Fidelin K, Wyart C. Curr Biol. 2021 Aug 9;31(15):3315-3329.e5. doi: 10.1016/j.cub.2021.05.042. Epub 2021 Jun 18.
• A norepinephrine-dependent glial calcium wave travels in the spinal cord upon acoustovestibular stimuli. Orts-Del'Immagine A, Dhanasekar M, Lejeune FX, Roussel J, Wyart C. Glia. 2022 Mar;70(3):491-507. doi: 10.1002/glia.24118. Epub 2021 Nov 13.
• A lexical approach for identifying behavioural action sequences. Reddy G, Desban L, Tanaka H, Roussel J, Mirat O, Wyart C. PLoS Comput Biol. 2022 Jan 10;18(1):e1009672. doi: 10.1371/journal.pcbi.1009672. eCollection 2022 Jan.
• Evolutionary divergence of locomotion in two related vertebrate species. Rajan G, Lafaye J, Faini G, Carbo-Tano M, Duroure K, Tanese D, Panier T, Candelier R, Henninger J, Britz R, Judkewitz B, Gebhardt C, Emiliani V, Debregeas G, Wyart C, Del Bene F. Cell Rep. 2022 Mar 29;38(13):110585. doi: 10.1016/j.celrep.2022.110585.
• Fluctuating landscapes and heavy tails in animal behavior. Costa AC, Sridhar G, Wyart C, Vergassola M. ArXiv [Preprint]. 2024 Apr 16:arXiv:2301.01111v4.
• Granger causality analysis for calcium transients in neuronal networks, challenges and improvements. Chen X, Ginoux F, Carbo-Tano M, Mora T, Walczak AM, Wyart C. Elife. 2023 Feb 7;12:e81279. doi: 10.7554/eLife.81279.
• CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Prendergast AE, Jim KK, Marnas H, Desban L, Quan FB, Djenoune L, Laghi V, Hocquemiller A, Lunsford ET, Roussel J, Keiser L, Lejeune FX, Dhanasekar M, Bardet PL, Levraud JP, van de Beek D, Vandenbroucke-Grauls CMJE, Wyart C. Curr Biol. 2023 Mar 13;33(5):940-956.e10. doi: 10.1016/j.cub.2023.01.039. Epub 2023 Feb 14.
• Unraveling the roles of cerebrospinal fluid-contacting neurons. Wyart C. Elife. 2023 Mar 24;12:e87054. doi: 10.7554/eLife.87054.
• Loss of CSF-contacting neuron sensory function is associated with a hyper-kyphosis of the spine reminiscent of Scheuermann's disease. Marie-Hardy L, Slimani L, Messa G, El Bourakkadi Z, Prigent A, Sayetta C, Koëth F, Pascal-Moussellard H, Wyart C, Cantaut-Belarif Y. Sci Rep. 2023 Apr 4;13(1):5529. doi: 10.1038/s41598-023-32536-1.
• Mechanosensory Control of Locomotion in Animals and Robots: Moving Forward. Dallmann CJ, Dickerson BH, Simpson JH, Wyart C, Jayaram K. Integr Comp Biol. 2023 Aug 23;63(2):450-463. doi: 10.1093/icb/icad057.
• [Polymodal sensory integration at the interface with the cerebrospinal fluid]. Wyart C. Med Sci (Paris). 2023 Jun-Jul;39(6-7):537-543. doi: 10.1051/medsci/2023082. Epub 2023 Jun 30.
• Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Wyart C, Jim KK, Prendergast AE. Neuroscience. 2023 Aug 10;525:47-50. doi: 10.1016/j.neuroscience.2023.07.008. Epub 2023 Jul 5.
• Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS. Wyart C, Carbo-Tano M, Cantaut-Belarif Y, Orts-Del'Immagine A, Böhm UL. Nat Rev Neurosci. 2023 Sep;24(9):540-556. doi: 10.1038/s41583-023-00723-8. Epub 2023 Aug 9.
• SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart C, Lehtinen MK. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551512. doi: 10.1101/2023.08.01.551512. Update in: Fluids Barriers CNS. 2023 Dec 5;20(1):89. doi: 10.1186/s12987-023-00491-8.
• Design of mechanosensory feedback during undulatory locomotion to enhance speed and stability. Wyart C, Carbo-Tano M. Curr Opin Neurobiol. 2023 Dec;83:102777. doi: 10.1016/j.conb.2023.102777. Epub 2023 Sep 2.
• The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish. Carbo-Tano M, Lapoix M, Jia X, Thouvenin O, Pascucci M, Auclair F, Quan FB, Albadri S, Aguda V, Farouj Y, Hillman EMC, Portugues R, Del Bene F, Thiele TR, Dubuc R, Wyart C. Nat Neurosci. 2023 Oct;26(10):1775-1790. doi: 10.1038/s41593-023-01418-0. Epub 2023 Sep 4.
• Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish. Jia X, Wyart C. Methods Mol Biol. 2024;2707:125-140. doi: 10.1007/978-1-0716-3401-1_8.
• The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid. Bellegarda C, Zavard G, Moisan L, Brochard-Wyart F, Joanny JF, Gray RS, Cantaut-Belarif Y, Wyart C. Elife. 2023 Sep 29;12:e86175. doi: 10.7554/eLife.86175.
• SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart C, Lehtinen MK. Fluids Barriers CNS. 2023 Dec 5;20(1):89. doi: 10.1186/s12987-023-00491-8.
• Uncovering multiscale structure in the variability of larval zebrafish navigation. Sridhar G, Vergassola M, Marques JC, Orger MB, Costa AC, Wyart C. bioRxiv [Preprint]. 2024 May 16:2024.05.16.594521. doi: 10.1101/2024.05.16.594521.
• Norepinephrine changes behavioral state via astroglial purinergic signaling. Chen AB, Duque M, Wang VM, Dhanasekar M, Mi X, Rymbek A, Tocquer L, Narayan S, Prober D, Yu G, Wyart C, Engert F, Ahrens MB. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595576. doi: 10.1101/2024.05.23.595576.
• Uncovering multiscale structure in the variability of larval zebrafish navigation. Sridhar G, Vergassola M, Marques JC, Orger MB, Costa AC, Wyart C. ArXiv [Preprint]. 2024 May 27:arXiv:2405.17143v1.
• Antinucci*, P, Dumitrescu*, AS, Deleuze, C, Morley, HJ, Leung, K, Hagley, T, Kubo, F, Baier, H, Bianco, IH#, Wyart, C#. A calibrated optogenetic toolbox of stable zebrafish opsin lines, eLife 2020;9:e54937.
• Orts-Del’Immagine, A, Cantaut-Belarif, Y,*, Thouvenin, O, Roussel, J, Baskaran, A, Langui, D, Koeth, F, Bivas, P, Lejeune, FX, Bardet, PL, WYART C# [2020]. Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo. Current Biology.
• Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart, C# [2020]. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLife, pii: e47699.
• Sternberg, JR, Prendergast, AE#, Brosse, L, Cantaut-Belarif, Y, Thouvenin, O, Orts-Dell’Immagine, A, Castillo, L, Djenoune, L, Kurisu, S, McDearmid, JR, Bardet, PL, Boccara, C, Okamoto, H, Delmas, P, Wyart, C # [2018] Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9:3804
• Cantaut-Belarif Y, Sternberg J, Thouvenin O, WYART C#, Bardet PL# [2018]. The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis [2018]. Current Biology 28:2479-2486.e4.