Speaker : Eric NESTLER, Nash Family Professor of Neuroscience and Psychiatry Interim Dean, Icahn School of Medicine at Mount Sinai Chief Scientific Officer, Mount Sinai Health System
"Transcriptional and Epigenetic Mechanisms of Drug Addiction"
Drug addiction can be viewed as a stable form of drug-induced neural plasticity, whereby long-lasting changes in gene expression mediate some of the stable behavioral abnormalities that define an addicted state. We have used large genome-wide datasets to identify transcription factors and chromatin modifications that mediate these adaptations. Some mechanisms represent homeostatic adaptations that oppose drug action and mediate aspects of drug tolerance and dependence, whereas others exert the opposite effect and contribute to sensitized drug responses. Parallel work has focused on homologous regions in the brains of addicted humans examined postmortem. These advances can now be mined to develop improved diagnostic tests and treatments for substance use disorders in humans.
Hosted by Stéphanie DEBETTE.
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Conference location
Please join the conference in Paris Brain Institute auditorium.