Structural Dynamics of Neural Networks

• Investigating the molecular mechanism controlling the extension dynamics of neuronal processes in the adult brain
• Generate new knowledge on the interaction of neurons and the vascular system during plasticity processes
• Develop a 3-D calcium imaging methodology in the animal in correlation with mapping neural markers and whole brain connections.
• Determining the role of structural plasticity in behavioural changes in mice

Main publications

• Kirst, C., Skriabine, S., Vieites-Prado, A., Topilko, T., Bertin, P., Gerschenfeld, G., Verny, F., Topilko, P., Michalski, N., Tessier-Lavigne, M., Renier, N. (2020). Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature Cell 180(4), 780-795.e25. (IF=28.7).
• Renier N., Dominici C., Erzurumlu R.S., Kratochwil C.F., Rijli F.M., Gaspar P. & Chédotal A. (2017). A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex. eLife, 6, 700. (IF=8.3).
• Renier N.*, Adams E. L.*, Kirst C.*, Wu Z.*, Azevedo R., Kohl J., et al. (2016). Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes. Cell, 165(7), 1789–1802. (IF=28.7).
• Renier N.*, Wu Z.*, Simon D.J., Yang J., Ariel P., & Tessier-Lavigne M. (2014). iDISCO: a simple,rapid method to immunolabel large tissue samples for volume imaging. Cell, 159(4), 896–910. (IF=28.7).
• Xu K.*, Wu Z.*, Renier N.*, Antipenko A., Tzvetkova-Robev D., Xu Y., et al. (2014). Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344(6189), 1275–1279. (IF=34.7).