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Causes of ALS and mechanisms of motor neural degeneration

Portrait Séverine Boilée
Séverine BOILLÉE

PhD, Team Leader, PI, INSERM

Team presentation

The team led by Séverine BOILLEE is interested in the mechanisms that induce motoneuron degeneration in ALS and that may result from a deleterious interaction between these neurons and microglial and macrophage cells (immune system cells).

The team’s goal is to identify pathways as therapeutic targets for slowing disease progression through 2 approaches:

  • To understand how mutations in known or identifiable genes cause motoneuron death and microglial dysfunction.
  • Discovering new therapeutic targets related to the immune system and the periphery (rather than the central nervous system (easier to access than the brain) by modulating the response of peripheral macrophages to spinal cord motoneuron degeneration.
Main publications

Main publications

Team members

Portrait Séverine Boilée
Séverine BOILLÉE

PhD, Team Leader, PI, INSERM

Portrait Delphine Bohl
Delphine BOHL

PhD, PI, INSERM

Portrait Christian LOBSIGER
Christian LOBSIGER

PhD, PI, INSERM

Portrait Stéphanie MILLECAMPS
Stéphanie MILLECAMPS

PhD, PharmD, PI, CNRS

News from the team

Les nerfs moteurs présents dans la moelle épinière se projettent vers la périphérie, où ils entrent en contact avec les muscles, formant des connexions appelées jonctions neuromusculaires. Crédit : James N. Sleigh.
Ultrasound show unexpected effects on motor neuron disease
Over the past fifteen years, neurosurgeons have been perfecting a fascinating technique: using ultrasound to temporarily open the blood-brain barrier to facilitate the action of therapeutic molecules in the central nervous system. At Paris Brain ...
09.05.2024 Research, science & health
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A promising therapeutic approach in amyotrophic lateral sclerosis (ALS)
Paris, October 19th, 2020 - ALS is characterized by the degeneration of motor neurons resulting in a progressive and irreversible deficit in walking and speech, until a complete paralysis of all muscles, including those controlling respiration. The ...
10.20.2020 Research, science & health