The workshop “Experimental and Computational Advances on APP and Amyloid-β Research” will bring together leading experts to address a central challenge in Alzheimer’s disease (AD) research: understanding the structure, aggregation, and biological impact of amyloid-β (Aβ) species and their relationship with amyloid precursor protein (APP).
The scientific program will open with recent advances in the structural characterization of toxic Aβ oligomers, highlighting the synergy between enhanced sampling simulations, machine learning-based structure prediction, and experimental techniques such as NMR, cryo-electron microscopy, and FTIR spectroscopy. A second session will focus on Aβ aggregation mechanisms, emphasizing pathways, kinetics, and their links to neurotoxicity. The third session will address the role of APP and its derived fragments in brain development and AD, including insights into the catalytic mechanisms of secretases and their impact on Aβ production. The final session will explore emerging therapeutic and biomarker strategies, with a focus on their effects on Aβ aggregation and clearance. The workshop will combine invited talks, short presentations, and poster sessions to ensure both depth and diversity of scientific exchange. Invited speakers will deliver 25-minute presentations followed by discussion periods, providing critical overviews of key research areas and emerging directions. Shorter presentations will be dedicated to postdoctoral researchers and PhD students, fostering early-career engagement and visibility within the community. Poster sessions will further encourage informal interactions, enabling participants to exchange ideas and develop collaborations. The invited speakers have been selected to ensure a strong balance between experimental and computational approaches, reflecting the interdisciplinary nature of the field. To promote active participation and maintain a high level of engagement, the workshop is designed as a focused two-day event, accommodating 50-60 participants.
Speakers
Ramanmoorthy Ayyalusamy, Yeongjin Baek, Sébastien Balme, Gargi Banerjee, Lucía Chávez Gutiérrez, Frédéric Checler,Nikolay V. Dokholyan, Marta Badia Graset, Christelle Hureau, Mathias Jucker, Andrey V. Kajava, Mai S. Li, Thomas CT Michaels, Yifat Miller, Phuong Nguyen, Raphaelle Pardosi, Marie-Claude Potier, Bern Reif, Harald Steiner, Martin Zacharias
Type of audience
General public / scientists
Language preference
English / French / Both
General Information
Dates: October 20-21, 2026
Registration deadline: September 18, 2026
Confirmation of registration: by 24 September 2026 at the latest
Location: Paris Brain Institute, Pitié-Salpêtrière Hospital Campus, Paris 13