Stéphane HAÏK
Title: MD, PhD
Function: Team Leader, PI
Affiliated entities INSERM
Biography
Stéphane Haïk is co-leader of the team on Alzheimer’s Disease and Prion Diseases at Paris Brain Institute, Director of Research at the CNRS and coordinator of the national reference centre for non-conventional transmissible agents. He holds a doctorate (1997) and a thesis supported at the Université Paris V René Descartes (2003). He received the Prix de l’Internat/Paris-2000 and an Inserm Avenir award in 2005. He is an external expert reader for many newspapers and national agencies involved in risk assessment and public safety.
Research
Neurobiology and Neurology of Prion and Prion-like Diseases
The team of Marie-Claude Potier and Stéphane Haïk is interested in the role of lipids, particularly cholesterol and Apolipoprotein E (ApoE), in the secretion and neural transport of Aß peptide, in the endosomal changes that occur in early disease, and in the Aß peptide toxicity mechanisms identified in vivo.
Dr. Haïk’s team is studying the development of pre-mortem diagnostic procedures for prion diseases, the characterization of emerging human prion strains, and the molecular and cellular mechanisms determining the selection, spread and pathogenicity of prion strains in the human brain.