Experimental Therapeutics of Parkinson's Disease

The team is working on the hypothesis that disease progression may be due in part to pathological cellular interaction networks, including neuroimmune interactions.

The 4 main goals of the “Experimental Therapeutics of Parkinson’s Disease” team are:

• To identify the role of protein aggregates (a-Syn and Tau) on microglial cell response and inflammatory polarization.
• Understanding how vascular changes observed in patients modulate neuroinflammation and aggregate "cleansing"
• To define the consequences of progressive dysfunction of non-dopaminergic neurotanning agents on inflammatory polarization and immune cell function
• To identify the role of environmental factors on the modulation of neuroimmune responses and the pathophysiology of PD.

Main publications

• Dos-Santos-Pereira M, Guimarães FS, Del-Bel E, Raisman-Vozari R, Michel PP. Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF- B-dependent signaling and glucose consumption. Glia. 2020 68(3):561-573.2. Parillaud VR, Lornet G, Monnet Y, Privat AL, Haddad AT, Brochard V, Bekaert A, de Chanville CB,
• Hirsch EC, Combadière C, Hunot S, Lobsiger CS. Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over induction of monocyte-attracting CCL2 by astrocytes. J Neuroinflammation. 2017 21;14(1):60.3. Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y,
• Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D. Hippocampal T cell infiltration promotesneuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017 140(1):184-200.4. 
• Mécharles S., Herrmann C., Poullain P., Tran T.H., Deschamps N., Mathon G., Landais A., Breurec S., Lannuzel A. Acute myelitis due to Zika virus infection. Lancet. 2016 2; 387(10026):1481.5. 
• Michel P.P., Hirsch E.C., Hunot S. Understanding Dopaminergic Cell Death Pathways in Parkinson Disease. Neuron. 2016 18; 90:675-91