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Imagerie médicale hirsch

Experimental Therapeutics of Parkinson's Disease

Etienne HIRSH
Etienne HIRSCH

PhD, Team Leader, PI, CNRS

Stéphane HUNOT
Stéphane HUNOT

PhD, Team Leader, PI, CNRS

Team presentation

The "Experimental Therapeutics of Parkinson’s Disease" team is interested in understanding the mechanisms behind PD progression and identifying and validating new treatments.

The team is working on the hypothesis that disease progression may be due in part to pathological cellular interaction networks, including neuroimmune interactions.

The 4 main goals of the “Experimental Therapeutics of Parkinson’s Disease” team are:

  • To identify the role of protein aggregates (a-Syn and Tau) on microglial cell response and inflammatory polarization.
  • Understanding how vascular changes observed in patients modulate neuroinflammation and aggregate "cleansing"
  • To define the consequences of progressive dysfunction of non-dopaminergic neurotanning agents on inflammatory polarization and immune cell function
  • To identify the role of environmental factors on the modulation of neuroimmune responses and the pathophysiology of PD.
Main publications

Main publications

Team members

Etienne HIRSH
Etienne HIRSCH

PhD, Team Leader, PI, CNRS

Stéphane HUNOT
Stéphane HUNOT

PhD, Team Leader, PI, CNRS

Photo de Patrick MICHEL
Patrick MICHEL

Project Sponsor, PhD, PI, Framework EPIC

Photo de Rita RAISMAN-VOZARI
Rita RAISMAN-VOZARI

PhD, DR2 emerite, PI, CNRS

Photo d'Annie LANNUZEL
Annie LANNUZEL

Project Sponsor, MD, PhD PU-PH, PI, Sorbonne Université, AP-HP

News from the team

Une nouvelle voie thérapeutique envisagée dans la maladie de Parkinson
New therapeutic approach expected in parkinson's disease
Rita Raisman-Vozari, and Patrick Michel, researchers from Etienne Hirsch's team at the Institut du Cerveau - ICM (CNRS, Inserm, UPMC), as well as other researchers from the Biomolecular, Conception, Isolation and Synthesis Lab (CNRS/ParisSud ...
09.13.2016 Research, science & health