Myelin Plasticity and Regeneration

The team’s previous work has shown that oligodendrocyte precursors are influenced by neuronal activity and signals from immune cells, underscoring the importance of these interactions in remyelination.

The Myelin Plasticity and Regeneration Team projects have 3 main objectives:

• Study the role of:
  • neuronal activity,
  • immune cells in oligodendrocyte differentiation and myelin regeneration, and understand the effects of these signals on differentiation of human myelinating cells,
• Develop innovative tools to identify and validate the therapeutic value of new promyelinizing molecules.

Main publications

• Maas DA, Eijsink VD, Spoelder M, van Hulten JA, De Weerd P, Homberg JR, Vallès A, Nait-Oumesmar B*, Martens GJM* (2020) Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia. Nat Commun 11(1):2329. *Equally contributed
• Chew LJ, Ming X, McEllin B, Dupree J, Hong E, Catron M, Fauveau M, Nait-Oumesmar B, Gallo V (2019) Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair. Cell Rep 29(10):3173 3186.
• Garcia-Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, Charnay P, Topilko P, Baron-Van Evercooren A (2019) Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 138(3):457-476.
• Maglorius Renkilaraj MRL, Baudouin L, Wells CM, Doulazmi M, Wehrlé R, Cannaya V, Bachelin C, Barnier JV, Jia Z, Nait Oumesmar B, Dusart I, Bouslama-Oueghlani L (2017) The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation. Neurobiol Dis. 98:137-148.
• El Behi M.*, Sanson C.*, Bachelin C., Guillot-Noël L., Fransson J., Stankoff B., Maillart E., Sarrazin N., Guillemot V., Abdi H., Cournu-Rebeix I.**, Fontaine B.**, Zujovic V.** (2015) Adaptive human immunity drives remyelination in a mouse model of demyelination. Brain 140(4):967-98.
  *Equally contributed