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Imagerie cérébrale Oumesmar Zujovic

Myelin Plasticity and Regeneration

Brahim NAIT OUMESMAR
Brahim NAIT OUMESMAR

PhD, Team Leader, PI, INSERM

Portrait Violetta
Violetta ZUJOVIC

PhD, Team Leader, PI, INSERM

Team presentation

The goal of the Myelin Plasticity and Regeneration team is to better understand the mechanisms underlying myelin plasticity and regeneration.

The team’s previous work has shown that oligodendrocyte precursors are influenced by neuronal activity and signals from immune cells, underscoring the importance of these interactions in remyelination.

The Myelin Plasticity and Regeneration Team projects have 3 main objectives:

  • Study the role of:
    • neuronal activity,
    • immune cells in oligodendrocyte differentiation and myelin regeneration, and understand the effects of these signals on differentiation of human myelinating cells,
  • Develop innovative tools to identify and validate the therapeutic value of new promyelinizing molecules.
Main publications

Main publications

Team members

Portrait Violetta
Violetta ZUJOVIC

PhD, Team Leader, PI, INSERM

Brahim NAIT OUMESMAR
Brahim NAIT OUMESMAR

PhD, Team Leader, PI, INSERM

Photo de Lamia BOUSLAMA
Lamia BOUSLAMA

Project Sponsor, PhD, MCU, PI, Sorbonne Université

News from the team

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A new anti-inflammatory mechanism identified
The team " Plasticity and regeneration of myelin" co-directed by Brahim NAIT-OUMESMAR, Inserm Research Director at the Paris Brain Institute - in collaboration with Angela Giangrande's team (IGBMC, Illkirch) has just demonstrated that the Gcm2 gene ...
10.25.2022 Research, science & health
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A gene involved in certain types of intellectual disability regulates myelin sheath development
Myelin, a protective sheath that covers various nerve fibers, is essential in the transmission of nerve signals and enables proper function of the nervous system. Myelin degeneration causes severe illnesses including multiple sclerosis. Lamia ...
02.03.2017 Research, science & health