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Imagerie cérébrale Lubetzki Stankoff

Alzheimer’s disease, prion diseases

Marie-Claude POTIER
Marie-Claude POTIER

PhD, Team Leader, PI

Stéphane HAÏK
Stéphane HAÏK

MD, PhD, Team Leader, PI, INSERM

Team presentation

The team is interested in the molecular mechanisms involved in the initiation and progression of Alzheimer’s disease and prion diseases.

The 5 main objectives are:

  • To study the interactions between cholesterol and APP peptide to modulate the production of amyloid aggregates.
  • Characterize subcellular compartments where protein production is initiated.
  • To study the role of the cerebral lymphatic system in the drainage of pathological proteins.
  • To determine if specific proteins can be observed in patients with a different clinical profile.
  • To study the mechanisms involved in the specific targeting of certain brain structures.

Alzheimer’s disease is a neurodegenerative disease that causes a progressive decline in cognition and memory. It is characterized by the appearance of lesions that gradually invade the brain and destroy neurons. Within the lesions, there is the excessive production and accumulation of amyloid-beta proteins that form plaques, called amyloid plaques or senile plaques, and the accumulation of modified proteins (Hyperphosphorylated Tau) that form neurofibrillary degeneracies that destroy neurons. These malfunctions result in disorganization of neural networks, leading to cognitive decline and then dementia. Prion diseases are rare diseases, characterized by degeneration of the central nervous system and the formation of aggregates of a specific misordered protein that accumulates, the prion protein. The most common is Creutzfeldt-Jakob Disease (CJD).

Main publications

Main publications

Team members

Marie-Claude POTIER
Marie-Claude POTIER

PhD, Team Leader, PI

Stéphane HAÏK
Stéphane HAÏK

MD, PhD, Team Leader, PI, INSERM

Photo de Nicolas BIZAT
Nicolas BIZAT

Project Sponsor, PhD, MCU, PI, Sorbonne Université

Photo de Susana BOLUDA
Susana BOLUDA

Project Sponsor, MD, PhD, PH, PI, AP-HP

Photo de Benoît DELATOUR
Benoît DELATOUR

Project Sponsor, PhD, CR1, PI, CNRS

Photo de Serge MARTY
Serge MARTY

Project Sponsor, PhD, CR1, PI, CNRS

Photo d'Isabelle PLU
Isabelle PLU

MCU, PI, AP-HP

Photo de Nicolas VILLAIN
Nicolas VILLAIN

Associate Researcher, PI

Photo de Foudil LAMARI
Foudil LAMARI

Associate Investigator, Neurometabolic Biochemistry, PI, AP-HP

Photo de Jean-Philippe BRANDEL
Jean-Philippe BRANDEL

Clinician, MD, PH, PI, AP-HP

Photo de Jean-Leon THOMAS
Jean-Leon THOMAS

Project Sponsor, PhD, DR1, PI, INSERM

Photo de Stéphanie LENCK
Stéphanie LENCK

Interventional Neuroradiologist, PhD student, PI

News from the team

charles duyckaerts
Homage to Charles Duyckaerts
It is with deep sadness that we inform you of the death of our colleague and friend, Prof. Charles Duyckaerts, who left us on the evening of Saturday, August 6, after several years of battling illness. ...
08.10.2022 Institutional
cerveau
Predicting the risk of developing Alzheimer's disease using genetic markers?
Although Alzheimer's disease is not hereditary in 99% of cases, genetic factors can increase the risk of developing it. The "Alzheimer's disease, prion diseases" team, co-directed by Marie-Claude Potier (CNRS) at the Paris Brain Institute, has ...
03.24.2022 Research, science & health
image
A new model for therapeutic research in Creutzfeldt-Jakob disease
What if a worm allowed a quantum leap in research on prion diseases such as Creutzfeldt-Jakob disease? A recent study by Nicolas Bizat (University of Paris) and Stéphane Haïk (Inserm) at the Paris Brain Institute, published in the journal Brain ...
11.17.2021 Research, science & health
test biologique
A biological test to detect Creutzfeldt-Jakob Disease
Scientists from the French Blood Bank (Etablissement français du sang), in collaboration with several researchers including Stéphane Haïk, team leader at the Institut du Cerveau - ICM, have just developed a biological test capable of detecting the ...
12.22.2016 Research, science & health
prions
Prion diseases: a model for neurodegenerative disorders
The majority of neurodegenerative disorders, from Alzheimer's disease to amyotrophic lateral sclerosis to Parkinson's disease, share common features with prion diseases. ...
12.09.2015 Research, science & health
image
Creutzfeldt-Jakob disease: new perspectives
An international clinical trial in Creutzfeldt-Jakob disease was conducted in France and Italy. Led in France by reasearchers from the Brain and Spinal institute (Jean Philippe Brandel and Stéphane Haïk), this study opens new perspectives for the ...
01.29.2011 Research, science & health