Remyelination in Multiple Sclerosis

The 5 main objectives are:

• Investigate mechanisms of myelination, demyelination and remyelination in different species, mice, xenops, humans
• Selecting and Validating New Remyelinating Molecules
• Understanding the molecular mechanisms of interaction between immune cells (microglia), myelinating cells and neurons during repair
• To study in human imaging the different components of the disease (inflammation, degeneration, energy dysregulation, repair), their chronological sequence and their clinical impact.
• Develop a clinical-bio-radiological stratification of patients, in order to optimize, through a personalized approach, the inclusions in innovative clinical trials.

Main publications

• Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet Neurol. 2020 Aug;19(8):678-688
• Bodini B*, Poirion E*, Tonietto M, Benoit M, Palladino R, Maillart E, Portera E, Battaglini M, Bera G, Kuhnast B, Louapre C, Bottlaender M, Stankoff B. Individual mapping of innate immune cell activation is a candidate marker of patient-specific trajectories of disability worsening in Multiple Sclerosis. J Nuc Med, 2020;61(7):1043 1049
• Dubessy AL, Mazuir E, Rappeneau Q, Ou S, Abi Ghanem C, Piquand K, Aigrot MS, Thétiot M,Desmazières A, Chan E, Fitzgibbon M, Fleming M, Krauss R, Zalc B, Ranscht B, Lubetzki C, Sol-Foulon N. Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. Glia. 2019 Dec;67(12):2248 2263
• Bodini B., Veronese M., Garcia-Lorenzo D., Battaglini M., Poirion E., Chardain A., Freeman L., Louapre C., Tchikviladze, Papeix C., Dolle F., Zalc B., Lubetzki C., Bottlaender M., Turkeimer F., Stankoff B. Dynamic imaging of individual remyelination profiles in multiple sclerosis. Ann Neurol, 2016 Feb 18. (cited in the Jan 2017 issue of Lancet Neurology as one of the best 5 papers in MS in 2016).
• Freeman S.A., Desmazières A., Simonnet J., Gatta M., Pfeiffer F., Aigrot M.S., Rappeneau Q., Guerreiro S., Michel P.P., Yanagawa Y., Barbin G., Brophy P.J., Fricker D, Lubetzki C., Sol-Foulon N. Acceleration ofconduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U SA 2015 Jan 20;112(3):E321-8.
• Freeman L., Garcia-Lorenzo D., Bottin L., Leroy C., Louapre C., Bodini B., Papeix C., Assouad R., Granger B., Tourbah A., Dollé F., Lubetzki C., Bottlaender M., Stankoff B. The neuronal component of gray matter damage in multiple sclerosis: a PET study