Bassem HASSAN
PhD, Team Leader, PI, Inserm
Team presentation
The "Brain Development" team, led by Bassem HASSAN, is interested in the formation of neurons and neural networks during brain development thanks to models of Drosophila and murine flies. The team is studying the transcriptional control of embryonic neural stem cells, as well as the emergence of visual circuits and neural networks responsible for behaviour and the transcriptional control of embryonic stem cells.
The 3 objectives of the Brain Development Team are:
- Investigating the role of proneural proteins in the genesis of neurons
- Demonstrate the link between neuronal excitability and individual innate behaviour
- Understanding the function of human genes associated with pathology during brain development
Main publications
- Linneweber GA, Andriatsilavo M, Dutta SB, et al. A neurodevelopmental origin of behavioral individuality in the Drosophila visual system.
Science. 2020;367(6482):1112–1119. - Ramaekers A, Claeys A, Kapun M, et al. Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between
Head Sensory Organs. Dev Cell. 2019. 50(6):780-92.e7 - Mora N, Oliva C, Fiers M, Ejsmont R, Soldano A, et al. A Temporal Transcriptional Switch Governs Stem Cell Division, Neuronal Numbers, and Maintenance of Differentiation. Dev Cell. 2018. 45(1):53-66.e5.
- Quan XJ, Yuan L, Tiberi L, Claeys A, De Geest N, et al. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis. Cell. 2016. 164(3):460-75.
- Langen M, Koch M, Yan J, De Geest N, Erfurth ML, et al. Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila. Elife. 2013. 2:e00337.
Team members
Bassem HASSAN
PhD, Team Leader, PI, Inserm
Carlos PARRAS
Project Sponsor, PhD, CR1, PI, INSERM
Laila EL KHATTABI
Genetics, PI, AP-HP
