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Dynamics of Epileptic Networks and Neuronal Excitability

Stéphane CHARPIER
Stéphane CHARPIER

PhD, PU, Team Leader, PI, Sorbonne Université

Mario CHAVEZ
Mario CHAVEZ

PhD, Team Leader, PI, CNRS

Vincent NAVARRO
Vincent NAVARRO

MD, PhD, Pr (PU-PH), Team Leader, PI

Team presentation

The team "Dynamics of Epileptic Networks and Neuronal Excitability" explores how the brain becomes epileptic (epileptogenesis), how it produces seizures (ictogenesis) and the relationships between neurophysiological activities and clinical semiology. The team is also exploring extreme brain conditions expressing continuous and abnormal electrical activities (isoelectric state and state of epileptic pain).

The team "Dynamics of Epileptic Networks and Neuronal Excitability" develops a multi-level translational approach, combining in vivo recordings in both epileptic patients and in animal models of spontaneous seizures, from the cortex to the basal ganglia. The objective of our approach is to better define the mechanistic links between the properties of single neurons and large-scale brain dynamics, and to elucidate the different facets of the pathophysiology of focal and generalized epilepsies.

To complement this research, the team is exploring the extreme brain conditions with continuous abnormal electrical activities (from isoelectric status to epilepsy to dying).

Main publications

Main publications

Schramm AE, Carton-Leclercq A, Diallo S, Navarro V, Chavez M, Mahon S, Charpier S (2020). Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia. Prog Neurobiol. 185:101733.
Lambrecq V., Lehongre K., Adam C., Frazzini V., Mathon B., Clemenceau S., Hasboun D., Charpier S., Baulac M., Navarro V., Le Van Quyen M. (2017) Single-unit activities during the transition to seizures in deep mesial structures. Ann Neurol.;82(6):1022 1028.
Williams M., Altwegg-Boussac T., Chavez M., Lecas S., Mahon S. and Charpier S. (2016). Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model. J Physiol. (London) 594: 6733-6751. This article was featured at the journal’s perspectives: Polack, P.O. (2016). J Physiol. (London) 594:6439-6751, 2016.
Navarro V., Dagron C., Elie C., Lamhaut L., Demeret S., Urien S., An K., Bolgert F., Tréluyer J.M., Baulac M., Carli P. (2016) Levetiracetam and clonazepam in status epilepticus: A prehospital doubleblind randomised trial. Lancet Neurology 15: 47-55.
Lopez-Persem A, Bastin J, Petton M, Abitbol R, Lehongre K, Adam C, Navarro V, Rheims S, Kahane P, Domenech P, Pessiglione (2020). Four core properties of the human brain valuation system demonstrated in intracranial signals. Nat Neurosci. 23(5): 664-675.

Team members

Stéphane CHARPIER
Stéphane CHARPIER

PhD, PU, Team Leader, PI, Sorbonne Université

Mario CHAVEZ
Mario CHAVEZ

PhD, Team Leader, PI, CNRS

Vincent NAVARRO
Vincent NAVARRO

MD, PhD, Pr (PU-PH), Team Leader, PI

Portrait Virginie LAMBRECQ
Virginie LAMBRECQ

Dr (MD, PhD), PI, Sorbonne Université, AP-HP

Portrait Séverine MAHON
Séverine MAHON

Dr (PhD), PI, INSERM

Portrait de Valerio FRAZZINI
Valerio FRAZZINI

Dr (MD, PhD), PI, INSERM, AP-HP

Portrait de Bertrand MATHON
Bertrand MATHON

Dr (MD, PhD), PI, Sorbonne Université, AP-HP

News from the team

vagues
Brain dynamics of the « wave of death » highlighted for the first time
When brain oxygenation is cut off for a prolonged period, the electrical activity of the cerebral cortex is quickly reduced to zero. But that’s not the end of the story… Researchers at Paris Brain Institute, coordinated by Séverine Mahon, have shown ...
12.13.2023 Research, science & health
épilepsie
Status epilepticus: new inflammatory markers to improve patient care
Unlike classic epileptic seizures that last only a few seconds or minutes, " status epilepticus" refers to a state of neuronal hyperactivity in the cerebral cortex that persists for several hours or days. When this condition occurs without a readily ...
03.31.2023 Research, science & health
image
Transcranial Magnetic Stimulation, what happens in the brain?
Transcranial Magnetic Stimulation (TMS) is a non-invasive stimulation procedure that uses transient electromagnetic fields to act in a focused manner on a particular brain region. It can be used as a therapy for depression, Parkinson's disease or ...
10.06.2022 Research, science & health
image
Status Epilepticus: new biomarkers to improve the prognosis of patients admitted to the ICU
A major neurological emergency, status epilepticus is defined as a persistent epileptic seizure. Exposing patients to irreversible brain lesions that cause serious cognitive sequelae, it requires intensive care, which may lead to sedation (artificial ...
07.06.2022 Research, science & health
Image pour visualiser l'épilepsie
When Epileptic seizures interrupt conscious processes: a step forward in neural mechanisms
During generalized seizures, in which epileptic activities affect the entire cerebral cortex, patients undergo an interruption of their conscious processes and are unable to deal efficiently with sensory stimuli. Using a genetic model of absence ...
09.07.2016 Research, science & health
Visuel d'un cerveau
Towards an experimental model for epilepsy?
For the first time, an animal model, deficient for DEPDC5 gene, responsible for familial focal epilepsy with cortical malformations, has been generated by Stéphanie Baulac and Eric Leguern's team. ...
03.09.2016 Research, science & health