Motivation, Brain and Behaviour

Motivation, Brain and Behaviour focuses on the cost-benefit trade-off that drives decisions:

• Identify how costs and benefits are represented in the brain
• Explain how the cost/benefit trade-off is mediated by cognitive control
• Study how this trade-off is biased by emotions and fatigue
• Characterize how this trade-off is modified by the pathologies and their treatment

Main publications

• Lopez-Persem A, Bastin J, Petton M, Abitbol R, Lehongre K, Adam C, Navarro V, Rheims S, Kahane P, Domenech P, Pessiglione M. Four core properties of the human brain valuation system demonstrated in intracranial signals. Nat Neurosci. 2020 May;23(5):664-675.
• Forgeot d’Arc B, Devaine M, Daunizeau J. Social behavioural adaptation
  in Autism. PLoS Comp. Biol. (2020), 16(3): e1007700.
• Borderies N, Bornert P., Gilardeau S., Bouret S. Pharmacological evidence for the implication of noradrenaline in effort. PLoS Biol. (2020)
• Blain B, Schmit C, Aubry A, Hausswirth C, Le Meur Y, Pessiglione M. Neuro-computational Impact of Physical Training Overload on Economic Decision-Making. Curr Biol. 2019 Oct 7;29(19):3289-3297.e4.
• Vinckier F, Rigoux L, Oudiette D, Pessiglione M. Neuro-computational
  account of how mood fluctuations arise and affect decision making. Nat Commun. 2018 Apr 26;9(1):1708.
• Pessiglione M, Vinckier F, Bouret S, Daunizeau J, Le Bouc R. Why not try
  harder? Computational approach to motivation deficits in neuro-psychiatric diseases. Brain. 2018 Mar 1;141(3):629-650.
• San-Galli A, Varazzani C, Abitbol R, Pessiglione M, Bouret S. Primate Ventromedial Prefrontal Cortex Neurons Continuously Encode the Willingness to Engage in Reward-Directed Behavior. Cereb Cortex. 2018 Jan 1;28(1):73-89.