PhD, Team Leader, PI
MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Team presentation
The objective of the "Genetics and Development of Brain Tumours" team is to identify new genetic mutations and biomarkers of brain tumours, as well as to understand the cellular and molecular mechanisms involved in their development.
The four main objectives are:
- Improving diagnosis and treatment by developing a molecular database
- Characterize the function of new mutations identified in gliomas using an analytical "pipeline" developed by the team
- Identify the intrinsic and microenvironment-related cellular mechanisms responsible for tumour development and progression
- Develop new mouse and human models for validating new treatments
Main publications
- Touat M et al. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 Apr;580(7804):517-523.
- Di Stefano AL et al. Clinical, Molecular and Radiomic Profile of Gliomas With FGFR3-TACC3 Fusions. Neuro Oncol 2020 May 15:noaa121. doi: 10.1093/neuonc/noaa121.
- D’Angelo F et al. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med. 2019 Jan;25(1):176-187.
- Idbaih A et al. Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma. Clin Cancer Res. 2019 Jul 1;25(13):3793-3801.
- Rosenberg S et al. A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas. Nat Commun. 2018 Jun 18;9(1):2371
- Labreche K et al. Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci. Acta Neuropathol. 2018 May;135(5):743-755.
- Peyre M, et al. Progestin-associated shift of meningioma mutational landscape. Ann Oncol 2018 Mar 1;29(3):681-686.
- Frattini V et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature. 2018 Jan 11;553(7687):222-227
Team members
PhD, Team Leader, PI
MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Clinician, MD,PhD,MCU-PH, PI, Sorbonne Université, AP-HP
Project Sponsor, MD, PhD, PU-PH, PI, Sorbonne Université, AP-HP
Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP
Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP
Clinician, MD, PhD, PH, PI, AP-HP
Clinician, MD, PhD, PU-PH, PI, Sorbonne Université, AP-HP
Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP
Project Sponsor, PhD, CRCN, PI, INSERM
Director of Research, PI, INSERM
Research Officer (CRCN), PI, INSERM
