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Genetics and Brain Tumour Development

Emmanuelle HUILLARD
Emmanuelle HUILLARD

PhD, Team Leader, PI

Marc SANSON
Marc SANSON

MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP

Team presentation

The objective of the "Genetics and Development of Brain Tumours" team is to identify new genetic mutations and biomarkers of brain tumours, as well as to understand the cellular and molecular mechanisms involved in their development.

The four main objectives are:

  • Improving diagnosis and treatment by developing a molecular database
  • Characterize the function of new mutations identified in gliomas using an analytical "pipeline" developed by the team
  • Identify the intrinsic and microenvironment-related cellular mechanisms responsible for tumour development and progression
  • Develop new mouse and human models for validating new treatments
Main publications

Main publications

Team members

Emmanuelle HUILLARD
Emmanuelle HUILLARD

PhD, Team Leader, PI

Marc SANSON
Marc SANSON

MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP

Photo de Matthieu PEYRE
Matthieu PEYRE

Clinician, MD,PhD,MCU-PH, PI, Sorbonne Université, AP-HP

Photo de Michel KALAMARIDES
Michel KALAMARIDES

Project Sponsor, MD, PhD, PU-PH, PI, Sorbonne Université, AP-HP

Photo de Franck BIELLE
Franck BIELLE

Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP

Photo de Mehdi TOUAT
Mehdi TOUAT

Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP

Photo de AGUSTI ALENTORN
Agusti ALENTORN

Clinician, MD, PhD, PH, PI, AP-HP

Photo de Khe HOANG-XUAN
Khe HOANG-XUAN

Clinician, MD, PhD, PU-PH, PI, Sorbonne Université, AP-HP

Photo d'Ahmed IDBAIH
Ahmed IDBAIH

Project Sponsor, MD, PhD, MCU-PH, PI, Sorbonne Université, AP-HP

Photo d'Isabelle LEROUX
Isabelle LEROUX

Project Sponsor, PhD, CRCN, PI, INSERM

Photo de Michel MALLAT
Michel MALLAT

Director of Research, PI, INSERM

Photo de Francesca BRANZOLI
Francesca BRANZOLI

Research Officer (CRCN), PI, INSERM

News from the team

senescence cellulaire
Cellular senescence plays a significant role in cerebral tumors
Glioblastomas are the most common malignant tumors of the adult brain. They resist conventional treatment, including surgery, followed by radiation therapy and chemotherapy. Despite thisarmamentarium, glioblastomas inexorably recur. In a new study ...
02.24.2023 Research, science & health
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Molecular characterization of primary lymphomas of the central nervous system towards a better prediction of evolution and personalized treatments
Researchers and clinicians from the research team co-directed by Prof. Marc SANSON and Emmanuelle HUILLARD at the Paris Brain Institute have just identified four molecular profiles of primary central nervous system lymphoma (PCNSL) that could predict ...
12.07.2022 Research, science & health
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GAB1, a good biomarker for Hedgehog-activated anterior skull base meningiomas
A study conducted by Julien Boetto and Franck Bielle (Sorbonne University. AP-HP) of the " Genetics and Development of Nervous System Tumours" team at the Paris Brain Institute highlights the potential of GAB1 as a new biomarker for Hedgehog ...
06.14.2021 Research, science & health