Speaker : Ariel LEVINE, National Institutes of Health (NIH)
"How to build the spinal cord"
In every part of our bodies, cell types and anatomy are organized to carry out specialized functions, and the dorsal horn of the mammalian spinal cord serves as a beautiful example. It is characterized by a dazzling array of cell types arranged in a layered microcircuit architecture, with each layer receiving different sensory and descending neural inputs and contributing unique roles to animal behavior. In contrast with the ventral horn of the vertebrate spinal cord, which is a textbook example of morphogen signaling and discrete embryonic lineage domains, the development of the dorsal horn has remained an enigma. It is known that nearly the entire dorsal horn is formed from a common pool of seemingly homogenous progenitors during late spinal neurogenesis, but how? I will present my team’s work on the developmental principles that shape the cell types and structure of the mouse spinal dorsal horn.
Hosted by Claire WYART
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Conference location
Please join the conference in Paris Brain Institute auditorium.
