EpiC

The team "Clinical and experimental epilepsy" develops a multi-level translational approach, combining in vivo recordings in both epileptic patients and in animal models of spontaneous seizures, from the cortex to the basal ganglia. The objective of our approach is to better define the mechanistic links between the properties of single neurons and large-scale brain dynamics, and to elucidate the different facets of the pathophysiology of focal and generalized epilepsies.

To complement this research, the team is exploring the extreme brain conditions with continuous abnormal electrical activities (from isoelectric status to epilepsy to dying).

Main publications

Lambrecq V., Lehongre K., Adam C., Frazzini V., Mathon B., Clemenceau S., Hasboun D., Charpier S., Baulac M., Navarro V., Le Van Quyen M. (2017) Single-unit activities during the transition to seizures in deep mesial structures. Ann Neurol.;82(6):1022 1028.

Williams M., Altwegg-Boussac T., Chavez M., Lecas S., Mahon S. and Charpier S. (2016). Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model. J Physiol. (London) 594: 6733-6751. This article was featured at the journal’s perspectives: Polack, P.O. (2016). J Physiol. (London) 594:6439-6751, 2016.

Navarro V., Dagron C., Elie C., Lamhaut L., Demeret S., Urien S., An K., Bolgert F., Tréluyer J.M., Baulac M., Carli P. (2016) Levetiracetam and clonazepam in status epilepticus: A prehospital doubleblind randomised trial. Lancet Neurology 15: 47-55.

Lopez-Persem A, Bastin J, Petton M, Abitbol R, Lehongre K, Adam C, Navarro V, Rheims S, Kahane P, Domenech P, Pessiglione (2020). Four core properties of the human brain valuation system demonstrated in intracranial signals. Nat Neurosci. 23(5): 664-675.

Calonge Q, Guinebretiere O, Nedelec T, Hanin A, Le Gac F, Chavez M, Tubach F, Tezenas Du Montcel S, Navarro V (2025) Recurrence and Mortality After a First Status Epilepticus: A Retrospective Nationwide Study From the French National Health Data System. Neurology 104(12):e213693

Vellieux G, Apartis E, Baudin P, Del Río Quiñones MA, Villemonte de la Clergerie D, Kas A, Navarro V, Lance-Adams Coinvestigators (2024) Multimodal Assessment of the Origin of Myoclonus in Lance-Adams Syndrome. Neurology 103(11):e209994

Ribierre T, Bacq A, Donneger F, Doladilhe M, Maletic M, Roussel D, Le Roux I, Chassoux F, Devaux B, Adle-Biassette H, Ferrand-Sorbets S, Dorfmüller G, Chipaux M, Baldassari S, Poncer JC, Baulac S (2024) Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy. Nat Neurosci. 27(6):1125-1136.

Carton-Leclercq A, Sofia Carrion-Falgarona S, Baudin P, Lemaire P, Lecas S, Topilko T, Charpier S, Mahon S (2023) Laminar organization of neocortical activities during systemic anoxia. Neurobiol Dis. 188:106345

Simonnet C, Sinha M, Goutierre M, Moutkine I, Daumas S, Poncer JC (2023) Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory. Neuropsychopharmacology 48(7):1067-1077.

Hanin A, Cespedes J, Dorgham K, Pulluru Y, Gopaul M, Gorochov G, Hafler DA, Navarro V, Gaspard N, Hirsch LJ (2023) Cytokines in New-Onset Refractory Status Epilepticus Predict Outcomes. Ann Neurol. 94(1):75-90

Schramm AE, Carton-Leclercq A, Diallo S, Navarro V, Chavez M, Mahon S, Charpier S (2020). Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia. Prog Neurobiol. 185:101733.

Kokolaki ML, Fauquier A, Renner M (2020) Molecular Crowding and Diffusion-Capture in Synapses. iScience 23(8):101382