Biography
Éric Leguern holds a Doctor of Medicine degree (1990) and a Science thesis from the University of Paris V (1991). He is a professor of medical genetics and a hospital practitioner in the Department of Genetics at the Pitié-Salpêtrière Hospital. There, he is responsible for the Laboratory of Molecular and Cellular Neurogenetics. He is also a member of several scientific committees and societies, including the European Academy of Sciences, the American Association of Neurology, the French Society of Neurology and the National Association of Practitioners in Molecular Genetics.
Research
Eric LEGUERN is interested in epileptic encephalopathies and genetic generalized epilepsy:
- To characterize the pathophysiologic mechanisms of HCN-1 epileptic encephalopathies by identifying new genetic causes of fever-associated epileptic encephalopathies.
- To understand how the mutations in several presynaptic proteins lead to generalized epilepsy.
Main publications
Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP; EuroEPINOMICS RES Consortium, Haaf T, LeGuern E, Depienne C (2014). De novo mutations in HCN1 cause early infantile epileptic encephalopathy. Nat Genet. Jun;46(6):640-5.