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Welcome to the “news” section of our website, where you'll find all the latest publications on our advances in research (Alzheimer's, Parkinson's, Charcot's disease, etc.), our upcoming events, etc.

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Loss of spatacsin function is accompanied by motoneuron degeneration.
A recent study carried out by Frédéric Darios in the team led by Alexis Brice at the Institut du Cerveau - ICM highlights the importance of spatacsin, a protein affected in pathologies such as hereditary spastic paraplegia.
04.03.2017 Research, science & health
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Hereditary spastic paraplegia and ALS: similarities in nervous system lesions
Hereditary spastic paraplegias are a heterogeneous group of pathologies and share clinical similarities with other neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).
04.01.2016 Research, science & health
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Hereditary spastic paraplegia: discovery of a new mechanism
A team at the Institut du Cerveau - ICM showed that different mutations of one gene, ALDH18A1, are associated with several types of hereditary spastic paraplegias and different modes of transmission. Moreover, the researchers identified a new blood...
11.24.2015 Research, science & health
motoneurone
Motorneurone diseases : 18 new causative genes
A research team of the Institut du Cerveau - ICM institute took part to an international study identifying 18 new genes implicated in hereditary spastic paraplegias (HSP). This work, published on January the 31th on the prestigious website of the...
02.06.2014 Research, science & health
MRI images of a SPG26 affected subject, with an enlarged corpus callosum in B (red arrow) and a cerebral atrophy in B’, (white arrow).
Hereditary Spastic Paraplegia: an improvement
Hereditary Spastic Paraplegia (HSP) are a genetically heterogeneous group of invalidating neurological disorders characterized by a progressive difficulty walking due to stiff legs (spastic) and additional neurological signs like epilepsy, ataxia...
07.31.2013 Research, science & health
Bottom line, from left to right : atrophy of the corpus callosum and of the cerebellum, abnormal structures of the mitochondrial network.
Hereditary spastic paraplegias: mutations in three novel genes highlight lipid metabolism in motor neuron degeneration
A research team directed by Giovanni Stevanin and Alexis Brice from the Brain and Spine Institute, in collaboration with other teams of the international SPATAX network (coordinator, Alexandra Durr), have identified 3 new causative genes in...
04.23.2013 Research, science & health