Neurophysiology of repetitive behaviours

The Neurophysiology of Repetitive Behaviours team has a translational approach and has access to patients and animal models suffering from repetitive pathological behaviours such as compulsions/impulses and stereotyping.

The three main objectives are:

• characterize the behavioural components that lead to repetitive behaviours
• identify the brain circuits involved in the acquisition and regulation of these repetitive behaviours
• understand how neuronal activity is modulated in these circuits

Principales publications

•  Senova S, Mallet L, …, Pelissolo A, Palfi S, Domenech P. Severe Obsessive Compulsive Disorder Secondary to Neurodegeneration With Brain Iron Accumulation: Complete Remission After Subthalamic Nuclei Deep Brain Stimulation. Biol Psychiatry, 2020 Jun 15;87(12):e39-e41.
• Welter M.L., Houeto J.L., Thobois S., …, Jalenques I., Karachi C., Mallet L. Anterior pallidal deep brain stimulation for Tourette’s syndrome: a double-blind randomised parallel controlled trial. Lancet Neurology 2017, S1474-4422(17)30160-6.
• Mondragon, L., & Burguiere, E. Bio-inspired benchmark generator for extracellular multi-unit recordings. Scientific Reports, 2017 Jan; 7, 43253.
• Domenech P., Redoute J., Koechlin E. and Dreher J.C. The Neuro Computational Architecture of Value-Based Selection in the Human Brain. Cerebral Cortex, 2017 Jan; 1-17.
• Burbaud P., Clair A.H., …, Welter M.L., Mallet L. Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder. Brain, 2013 Jan;136(Pt 1):304-17.
• Burguière E., Monteiro P., Feng G., Graybiel A.M. Optogenetic stimulation of lateral orbitofrontostriatal pathway suppresses compulsive behaviors. Science, 2013 Jun 7;340(6137):1243-6.