Skip to main content

Or 34,00 After 66% tax deduction

I make a monthly donation I make an IFI donation
Research, science & health

Moral emotions, a diagnotic tool for frontotemporal dementia ?

Published on: 07/06/2019 Reading time: 1 min
image

A study conducted by Marc Teichmann and Carole Azuar at the Brain and Spine Institute in Paris (France) and at the Pitié-Salpêtrière Hospital shows a particularly marked impairment of moral emotions in patients with frontotemporal dementia (FTD). The results, published in the Journal of Alzheimer’sDisease, open a new approach for early, sensitive and specific diagnosis of FTD.

Frontotemporal dementia is a cognitive and behavioral disease caused by degenerative alteration of anterior regions of the brain. The disease is characterized by behavioral disorders such as a progressive apathy, loss of interest, social withdrawal, loss of inhibition and the processing of emotions.

We have known for a long time that these patients demonstrate impairment of emotion recognition and of theory of mind i.e. the ability to figure out the mental states of others: what they think, what they feel, what they like…  But does this emotional blunting also affect a specific kind of emotions called moral emotions, which are crucial for human interactions?

Dr Marc Teichmann Coordinator of the study

Moral emotions can be defined as « affective experiences promoting cooperation and group cohesion » including emotions such as admiration, shame or pity. They are distinct from other emotions in that they are strongly linked to the cultural context, moral rules and innate moral representations. In the context of FTD, which are primarily characterized by an impairment of behavior and social interactions, studying these particular set of emotions is a major issue to better understand the disease and to refine diagnostic accuracy.

 

In the present study, researchers and clinicians from the Institut du Cerveau - ICM – Brain and Spine Institute and the Pitié-Salpêtrière Hospital developed a test to assess moral emotions. It is composed of 42 scenarios for which the subject has to select, out of 4 response possibilities, the feeling s/he has in the scenario situation. La performance des patients FTD (N=22) are compared to the performance of 45 healthy subjects and to 15 patients with Alzheimer’s disease. To evaluate the specificity of the impairment of moral emotions in FTD the researchers contrasted the 42 moral scenarios involving an inter-human context and eliciting moral emotions with scenarios eliciting similar emotions without any mral valence. For example, it is possible to feel admiration for both an altruistic act and the architecture of a building. In both cases, the emotion is identified as admiration but the context is entirely different (moral versus extra-moral).

 

The results show that moral emotions are much more impaired than emotions without moral valence. In contrast, patients with Alzheimer’s disease had no impairment as compared to healthy subjects and they had similar performance with moral and extra-moral emotions.

Our findings confirm that emotions in general are impaired in FTD and they reveal a particularly profound alteration of moral emotions. Our novel test tool appears to provide an early, sensitive and specific marker for FTD diagnosis while reliably distinguishing FTD from Alzheimer’s disease patients. It could also be a marker for other diseases involving the breakdown of moral emotions as for example in the case of psychopathic individuals.

Marc Teichmann

Sources

https://pubmed.ncbi.nlm.nih.gov/31127763/
Teichmann M, Daigmorte C, Funkiewiez A, Sanches C, Camus M, Mauras T, Le Ber I, Dubois B, Levy R, Azuar C. J Alzheimers Dis. 2019 May 20.

Our news on the subject

Le cortex moteur
Origin of Lance-Adams Syndrome Finally Elucidated
First described 60 years ago, chronic myoclonus following cerebral anoxia is now known as Lance-Adams syndrome. This is a severe disorder whose mechanisms were, until now, poorly understood. Geoffroy Vellieux, Vincent Navarro, and their colleagues at...
06.16.2025 Research, science & health
Tiré de New Theory of Colours de Mary Gartside, 1808
Aphantasia Might Be Linked to Alterations in Brain Connectivity
Thanks to 7T fMRI, researchers from Paris Brain Institute and NeuroSpin, the CEA's neuroimaging centre, are exploring the neural substrate of visual imagery at very high resolution for the first time. Their results, publiés [i] in Cortex, pave the...
06.06.2025 Research, science & health
Le développement du cerveau a une part d’aléatoire
The stochastic aspect of brain development
Although every person’s personality is the result of genetic and environmental factors, these are not the only factors at play. Bassem Hassan and his team at Paris Brain Institute have discovered that, in fruit flies (drosophila), individuality also...
05.12.2025 Research, science & health
Analyse MERSCOPE
New treatment pathways for brain malformation-linked focal epilepsy?
A study by Stéphanie Baulac’s team has revealed somatic mutations in different cell types in patients with type 2 focal cortical dysplasia. This disease causes drug-resistant epileptic seizures, for which the main treatment option is currently...
05.12.2025 Research, science & health
Un iceberg
The ICEBERG cohort, 10 years of collective scientific and medical mobilization
The ICEBERG cohort, initiated 10 years ago, is interested in studying factors predictive of the onset and progression of Parkinson’s disease.
05.15.2025 Research, science & health
La huntingtine est une protéine indispensable au développement embryonnaire, à la formation et au maintien du tissu cérébral.
Huntington's Disease: The Energy Hypothesis Gets Traction
Huntington's disease, a rare hereditary neurological disorder, is associated with an energy deficit that precedes the onset of symptoms and is closely linked to their progression. At Paris Brain Institute, Fanny Mochel and her colleagues are testing...
02.11.2025 Research, science & health
See all our news