Skip to main content

Or 34,00 After 66% tax deduction

I make a monthly donation I make an IFI donation
Research, science & health

Parkinson’s disease: a link between brain stem lesions and cardiac disorders

Published on: 02/02/2017 Reading time: 1 min
parkinson cardiaque

From the early stages of Parkinson’s disease onwards, cardiovascular and respiratory disorders are relatively frequent. The team led by Stéphane Lehéricy and Marie Vidailhet at the Institut du Cerveau – ICM highlighted, for the very first time, a link between these symptoms and damage to the medulla oblongata, an area of the brain stem involved in controlling vital functions.

The medulla oblongata is the lower part of the brain stem and is responsible for vital functions sur as breathing, heart rate and maintaining blood pressure. In patients with Parkinson’s disease, symptoms of dysfunction of these autonomous functions, notably cardiovascular function, are frequent. They are observed from the early stages of the illness and may precede motor symptoms.

This dysfunction may be caused by lesions of certain sympathetic and parasympathetic nervous system nodules in the medulla oblongata, involved in involuntary activity such as heart rate control and respiratory rate control. Lewy bodies, abnormal protein aggregates within cells, are present at the site of the nodules, and cellular degeneration is observed in patients with Parkinson’s disease.

Using diffusion-weighted MRI, a cutting-edge imaging technique, Institut du Cerveau – ICM researchers hoped to correlate medulla oblongata lesions with cardiac and respiratory disorders.

The study conducted on 52 patients with Parkinson’s disease found structural anomalies in the medulla oblongata in these patients. Structural modifications in this area are specifically correlated with heart problems, assessed based on heart rate variations and respiratory rate.

For the very first time, we have established a link between medulla oblongata anomalies observed using diffusion-weighted MRI and cardiovascular and respiratory disorders. This imaging technique could prove to be an interesting biomarker for Parkinson’s disease, leading to improved diagnosis and, hopefully, progression prediction.

Sources

https://www.neurology.org/content/early/2016/11/11/WNL.0000000000003426…
Nadya Pyatigorskaya, Marie Mongin, Romain Valabregue, Lydia Yahia-Cherif, Claire Ewenczyk, Cyril Poupon, Eden Debellemaniere, Marie Vidailhet, Isabelle Arnulf, and Stephane Lehéricy.

Our news on the subject

Le développement du cerveau a une part d’aléatoire
The stochastic aspect of brain development
Although every person’s personality is the result of genetic and environmental factors, these are not the only factors at play. Bassem Hassan and his team at Paris Brain Institute have discovered that, in fruit flies (drosophila), individuality also...
05.12.2025 Research, science & health
Analyse MERSCOPE
New treatment pathways for brain malformation-linked focal epilepsy?
A study by Stéphanie Baulac’s team has revealed somatic mutations in different cell types in patients with type 2 focal cortical dysplasia. This disease causes drug-resistant epileptic seizures, for which the main treatment option is currently...
05.12.2025 Research, science & health
Un iceberg
The ICEBERG cohort, 10 years of collective scientific and medical mobilization
The ICEBERG cohort, initiated 10 years ago, is interested in studying factors predictive of the onset and progression of Parkinson’s disease.
05.15.2025 Research, science & health
La huntingtine est une protéine indispensable au développement embryonnaire, à la formation et au maintien du tissu cérébral.
Huntington's Disease: The Energy Hypothesis Gets Traction
Huntington's disease, a rare hereditary neurological disorder, is associated with an energy deficit that precedes the onset of symptoms and is closely linked to their progression. At Paris Brain Institute, Fanny Mochel and her colleagues are testing...
02.11.2025 Research, science & health
À la recherche de marqueurs d’imagerie dans la démence frontotemporale
Searching for Imaging Markers in Frontotemporal Dementia
Could exploring the relationships between different brain networks help us understand frontotemporal dementia (FTD)? This neurodegenerative disease, which progresses at varying rates, is often diagnosed late—when clinical signs are already severe. At...
01.07.2025 Research, science & health
Monocyte – un globule blanc qui se différencie en macrophage. Crédit : Université d’Edinbourg.
Discovery of a Macrophage Anomaly in Multiple Sclerosis
Certain patients with multiple sclerosis (MS) can partially regenerate myelin—the protective sheath that surrounds nerve fibers—which is damaged during the evolution of the disease. In studying how immune cells influence this remyelination...
12.19.2024 Research, science & health
See all our news