Several teams at Paris Brain Institute are working on PSP, directly or indirectly The team of Profs Marie VIDAILHET and Stéphane LEHERICY is studying abnormal movement and brain imaging. Dr. Richard LEVY’s FRONTLAB team is interested in behavioural symptoms related to frontal lobe disease, such as apathy. A study by Drs. Marc TEICHMANN and Antony VALERO-CABRE has identified the beneficial effect of transcranial magnetic stimulation on certain symptoms of PSP. The ARAMIS team of Olivier COLLIOT and Stanley DURRLEMAN is developing artificial intelligence algorithms that would allow earlier diagnosis of PSP by differentiating patients with PSP from other parkinsonian syndromes on the basis of brain imaging.
Major Differences Between PSP and Parkinson's Disease
| Clinical Signs | Parkinson's disease | Progressive Supranuclear Paralysis |
| Postural Instability (Falls) | ✔ Delay | ✔ Precocious |
| Muscle Rigidity | ✔ Asymmetrical | ✔ Symmetrical |
| Vertical oculomotor disorders | ✗ | ✔ |
| Cognitive impairment (reasoning, attention,...) | Inconstructive / Latecomers | ✔ frequent |
| Fixed view | ✗ | ✔ |
| Symptoms on both sides of the body | ✔Asymmetrical | ✔Symmetrical |
