Skip to main content

Or 34,00 After 66% tax deduction

I make a monthly donation I make an IFI donation
Research, science & health

Multiple sclerosis and covid-19

Published on: 08/07/2020 Reading time: 1 min
Sclérose en plaques et COVID-19
Retour à la recherche

DOES MULTIPLE SCLEROSIS (MS) ALTER THE RISK OF DEVELOPING A SEVERE FORM OF COVID-19 INFECTION? WHAT ARE THE CLINICAL FEATURES AND EFFECTS OF CORONAVIRUS INFECTION IN PATIENTS WITH MS? DO SPECIFIC TREATMENTS FOR SEPSIS INCREASE OR DECREASE THE SEVERITY OF THE VIRAL INFECTION?

At the Paris Brain Institute, a study coordinated by Dr Céline LOUAPRE, neurologist (AP-HP.Sorbonne University), referent doctor of the Clinical Investigation Centre (CIC) and researcher in the team of Profs LUBETZKI and STANKOFF has made it possible to answer these questions.

The COVISEP register is based on a cohort of patients from all the expert centres and neurologists who follow MS patients in France. The retrospective and observational study, coordinated by Dr LOUAPRE, which was published in the scientific journal JAMA Neurology, involved 347 multiple sclerosis patients infected with COVID-19 between 1 March and 21 May 2020.

The severity of COVID-19 was assessed on a scale ranging from 1 (no hospitalisation, no activity limitation) to 7 (death).

Of the 347 patients included in the study, 284 were receiving immunomodulatory or immunosuppressive therapy for their MS. The rate of patients hospitalised due to COVID-19 was 21%, and the rate of COVID-19-related deaths was 3.5%, slightly higher than expected for a population with an average age of 44 years.

The results of this study show that the risk factors for COVID-19 severity (requiring at least hospitalisation) are EDSS score (a scale reflecting the severity of neurological disability), age and obesity. In contrast, immunomodulatory or immunosuppressive treatments were not associated with an increase in the severity of COVID-19.

These results now make it possible to better adapt the clinical management of multiple sclerosis patients presenting one of the risk factors identified in the case of COVID-19 contamination.

Sources

Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis  Céline LOUAPRE  et al.
PMID: 32589189  DOI: 10.1001/jamaneurol.2020.2581

Our news on the subject

La bibliothèque de Babel
Mental Time Travel: A New Case of Autobiographical Hypermnesia
Remembering past events in minute detail, revisiting them methodically, and reliving past emotions—this is the peculiarity of people with an exceptional memory of their own lives, known as autobiographical hypermnesia, or hyperthymesia. This...
08.28.2025 Research, science & health
Crédit : Ana Yael.
An International Database to Better Understand Dreams
In an article published in Nature Communications, researchers from 37 scientific institutions—including Paris Brain Institute—unveil the DREAM database: an ambitious project designed to centralize, share, and standardize data from research on sleep...
08.14.2025 Research, science & health
Le cortex moteur
Origin of Lance-Adams Syndrome Finally Elucidated
First described 60 years ago, chronic myoclonus following cerebral anoxia is now known as Lance-Adams syndrome. This is a severe disorder whose mechanisms were, until now, poorly understood. Geoffroy Vellieux, Vincent Navarro, and their colleagues at...
06.16.2025 Research, science & health
Tiré de New Theory of Colours de Mary Gartside, 1808
Aphantasia Might Be Linked to Alterations in Brain Connectivity
Thanks to 7T fMRI, researchers from Paris Brain Institute and NeuroSpin, the CEA's neuroimaging centre, are exploring the neural substrate of visual imagery at very high resolution for the first time. Their results, publiés [i] in Cortex, pave the...
06.06.2025 Research, science & health
Le développement du cerveau a une part d’aléatoire
The stochastic aspect of brain development
Although every person’s personality is the result of genetic and environmental factors, these are not the only factors at play. Bassem Hassan and his team at Paris Brain Institute have discovered that, in fruit flies (drosophila), individuality also...
05.12.2025 Research, science & health
Un iceberg
The ICEBERG cohort, 10 years of collective scientific and medical mobilization
The ICEBERG cohort, initiated 10 years ago, is interested in studying factors predictive of the onset and progression of Parkinson’s disease.
05.15.2025 Research, science & health
See all our news