MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Team presentation
The goal of the Frontlab team is to better understand the role and organization of the prefrontal cortex in the control, activation and inhibition of voluntary directed behaviours and its modulating effect on creative thinking and how it interacts structurally and functionally with other brain regions.
The team’s three research areas are:
- Pursue projects on neural networks involved in creativity, reasoning, apathy
- Develop basic research projects on the neuronal bases of impulsivity, on directed behaviours in natural environments
- To characterize and treat pathologies associated with frontal dysfunction.
The study of frontal functions makes it possible to understand how our most complex behaviours (decision-making, planning, reasoning, creativity, moral judgment, social interactions…) are developed and controlled. Thorough knowledge of the frontal lobes is also essential to better treat the many neurological and psychiatric diseases associated with these brain regions (Alzheimer’s disease, stroke, head injuries, depression, schizophrenia, etc.).
Main publications
- Migliaccio R et al. Cognitive and behavioural inhibition deficits in neurodegenerative dementias. Cortex 2020 (e-pub, ehead of print)
- Montembeault M et al. Cognitive inhibition impairments in presymptomatic C9orf72 carriers. J Neurol Neurosurg Psychiatry. 2020;91(4):366 372.
- Toba MN et al. Revisiting ‘brain modes’ in a new computational era: Approaches for the characterization of brain-behavioural associations. Brain 2020 ;143(4):1088-1098.
- Batrancourt B et al. Exploration deficit in ecological condition as a marker of apathy in frontotemporal dementia. Front. Neurol 2019; 10:941.
- Alves P et al. An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings. Communications Biology, 2019. 2, 370.
- Schreiweis C et al. A neuroscientific approach to increase gender equality. Nature Human Behavior 2019 ; 3 :1238–1239.
- Mandonnet E et al. Electrically induced verbal perseveration: A striatal deafferentation model. Neurology. 2019 Feb 5;92(6):e613-e621.
- Valero-Cabré A et al. Language boosting by transcranial stimulation in Progressive Supranuclear Palsy. Neurology 2019 93.
- Foulon C et al. Advanced lesion symptom mapping analyses and implementation as BCBtoolkit. GigaScience 2018 7; 1-17
- Bendetowicz D et al. Two critical brain networks for generation and combination of remote associations. Brain 2018 141 : 217-233
- Bertrand A et al. Early cognitive, structural and microstructural changes in c9orf72 presymptomatic carriers
Team members
MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP
Project Sponsor, MD, PhD, CR1, PI, INSERM
Project Sponsor, PhD, IR, PI, INSERM
Principal Investigator, PhD, CRCN, PI (Principal Investigator), INSERM
Project Sponsor, MD, PhD, DR2, PI, CNRS
Project Sponsor, MD, PhD, CR1, PI, INSERM
Associate Researcher, PI
Project Sponsor, MD, PhD, PU-PH, PI, Université Paris X, AP-HP
Project Sponsor, MD, PhD, PH, PI, Sorbonne Université, AP-HP
