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Frontlab

Functions and dysfunctions of systems

Richard LEVY
Richard LEVY

MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP

The goal of the Frontlab team is to better understand the role and organization of the prefrontal cortex in the control, activation and inhibition of voluntary directed behaviours and its modulating effect on creative thinking and how it interacts structurally and functionally with other brain regions.

The team’s three research areas are:

  • Pursue projects on neural networks involved in creativity, reasoning, apathy
  • Develop basic research projects on the neuronal bases of impulsivity, on directed behaviours in natural environments
  • To characterize and treat pathologies associated with frontal dysfunction.

The study of frontal functions makes it possible to understand how our most complex behaviours (decision-making, planning, reasoning, creativity, moral judgment, social interactions…) are developed and controlled. Thorough knowledge of the frontal lobes is also essential to better treat the many neurological and psychiatric diseases associated with these brain regions (Alzheimer’s disease, stroke, head injuries, depression, schizophrenia, etc.).

Main publications

Main publications

Team members

Richard LEVY
Richard LEVY

MD, PhD, Pr (PU-PH), Team Leader, PI, Sorbonne Université, AP-HP

Photo d'Emmanuelle VOLLE
Emmanuelle VOLLE

Project Sponsor, MD, PhD, CR1, PI, INSERM

Photo de Benedicte BATRANCOURT
Benedicte BATRANCOURT

Project Sponsor, PhD, IR, PI, INSERM

Photo d'Alizée LOPEZ-PERSEM
Alizée LOPEZ-PERSEM

Principal Investigator, PhD, CRCN, PI (Principal Investigator), INSERM

Photo d'Antoni VALERO-CABRE
Antoni VALERO-CABRE

Project Sponsor, MD, PhD, DR2, PI, CNRS

Photo de Raffaella Lara MIGLIACCIO
Raffaella Lara MIGLIACCIO

Project Sponsor, MD, PhD, CR1, PI, INSERM

Photo de Béatrice Garcin
Béatrice Garcin

Associate Researcher, PI

Photo d'Emmanuel MANDONNET
Emmanuel MANDONNET

Project Sponsor, MD, PhD, PU-PH, PI, Université Paris X, AP-HP

Photo de Isabelle LE BER
Isabelle LE BER

Project Sponsor, MD, PhD, PH, PI, Sorbonne Université, AP-HP

News from the team

lobes cerveau
Towards better management of disinhibition in frontotemporal dementia
Disinhibition is one of the main symptoms of the behavioural variant frontotemporal dementia (bvFTD), a type of dementia associated with degeneration of the frontal and temporal lobes of the brain. Patients with bvFTD exhibit behaviours that are ...
01.30.2023 Research, science & health
image
Transcranial Magnetic Stimulation, what happens in the brain?
Transcranial Magnetic Stimulation (TMS) is a non-invasive stimulation procedure that uses transient electromagnetic fields to act in a focused manner on a particular brain region. It can be used as a therapy for depression, Parkinson's disease or ...
10.06.2022 Research, science & health
cerveau
Alzheimer's disease, a complex genetic susceptibility
Although Alzheimer's disease is not inherited in 95% of cases, nearly 75 genetic susceptibility factors - that is, factors that increase the risk to develop the disease - or protective factors - that decrease the probability to be affected - have ...
07.11.2022 Research, science & health
Des personnages avec une ampoule qui symbolise la créativité
How do we explore our knowledge to be creative?
Coming up with a creative idea requires us to draw on all our previous knowledge. But how does this happen in our mind and in our brain? Emmanuelle Volle's group (Inserm) at the Frontlab of the Paris Brain Institute, in collaboration with the ...
06.29.2022 Research, science & health
cerveau
A better characterization of disinhibition in frontotemporal degeneration
Thanks to an approach combining behavioral assessment and brain imaging, a study conducted by the Paris Brain Institute's FrontLAB has led to a better characterization of a major symptom of frontotemporal degeneration, disinhibition. These results ...
06.20.2022 Research, science & health
confinement et créativité
How the first lockdown of the COVID-19 pandemic changed our creativity
Covid-19 took us by surprise and the exceptional situation of the first lockdown required great capacities of adaptation, in particular for our brain. A study conducted at the Paris Brain Institute (Inserm/CNRS/Sorbonne University/AP-HP) has just ...
05.10.2022 Research, science & health